Abstract
The application of molecular knowledge for developing new medical technologies is the goal of molecular medicine. Success in this area is highly dependent on the interaction of investigators from fields as diverse as biochemistry, cell biology, immunology, physiology, epidemiology, and physics, with an eye toward applying their insights and discoveries to improving human health. Such interdisciplinary approaches rarely find the common ground and language necessary to achieve this goal. Recently, a meeting of researchers studying the ectoenzymes CD38 and CD157 brought together insights into the regulation of calcium signaling, the metabolism of pyridine nucleotides by CD38 and CD157, and subsequent effects on immune function. Together, these discoveries were being applied to the development of novel therapeutics and diagnostics for myeloma and chronic lymphocytic leukemia. This issue of Molecular Medicine, featuring several short reviews based on a conference held in Turin, Italy, 10–12 June 2006, showcases the current state of this field and highlights some recent progress in molecular medicine.
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References
Zola H. (2006) Medical applications of leukocyte surface markers: the CD molecules. Mol Med 12(11–12) In press
Malavasi F, et al. (2006) CD38 and CD157 as receptors of the immune system. Mol Med 12(11–12) In press
Lund F. (2006) Signaling properties of CD38 in the mouse immune system: enzyme-dependent and independent roles in immunity. Mol Med 12(11–12) In press
Lee HC. (2006) Structure and enzymatic functions of human CD38. Mol Med 12(11–12) In press
Billington RA et al. (2006) Emerging functions of extracellular pyridine nucleotides. Mol Med 12(11–12) In press
Morabito F et al. (2006) The CD38 ectoenzyme facily: advances in basic science and clinical practice. Mol Med 12(11–12) In press
Stevenson GT. (2006) CD38 as a therapeutic target. Mol Med 12(11–12) In press
Acknowledgments
The authors thank Dr. Silvia Deaglio, Department of Genetics, Biology and Biochemistry, University of Torino, Italy, for assistance with preparing the figure.
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Czura, A.W., Czura, C.J. CD38 and CD157: Biological Observations to Clinical Therapeutic Targets. Mol Med 12, 309–311 (2006). https://doi.org/10.2119/2007-00006.Czura
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DOI: https://doi.org/10.2119/2007-00006.Czura