Molecular Medicine

, Volume 21, Issue 1, pp 87–97 | Cite as

Sirtuin 1: A Target for Kidney Diseases

  • Lili Kong
  • Hao Wu
  • Wenhua Zhou
  • Manyu Luo
  • Yi Tan
  • Lining Miao
  • Lu Cai
Review Article


Sirtuin 1 (SIRT1) is an evolutionary conserved NAD+-dependent histone deacetylase that is necessary for caloric restriction-related lifespan extension. SIRT1, as an intracellular energy sensor, detects the concentration of intracellular NAD+ and uses this information to adapt cellular energy output to cellular energy requirements. Previous studies on SIRT1 have confirmed its beneficial effects on cellular immunity to oxidative stress, reduction of fibrosis, suppression of inflammation, inhibition of apoptosis, regulation of metabolism, induction of autophagy and regulation of blood pressure. All of the above biological processes are involved in the pathogenesis of kidney diseases. Therefore, the activation of SIRT1 may become a therapeutic target to improve the clinical outcome of kidney diseases. In this review, we give an overview of SIRT1 and its molecular targets as well as SIRT1-modulated biological processes, with a particular focus on the role of SIRT1 in kidney diseases.



The citations from the authors group were supported in part by the National Science Foundation of China (81170669 to L Miao) and the National Institutes of Health (1R01DK 091338-01A1 to L Cai). We would like to thank Amy Y Cai for assistance in making the figures for this manuscript. We would also like to express our gratitude to all the scientists participating in this work.


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Authors and Affiliations

  1. 1.Department of NephrologyThe Second Hospital of Jilin UniversityChangchunChina
  2. 2.Kosair Children’s Hospital Research Institute, Department of PediatricsUniversity of LouisvilleLouisvilleUSA
  3. 3.Department of Pharmacology and ToxicologyUniversity of LouisvilleLouisvilleUSA

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