Molecular Medicine

, Volume 20, Supplement 1, pp S2–S6 | Cite as

A Surprising Journey in Translational Medicine

  • Anthony Cerami

As I look back over the course of my work, it is easy to see how ideas, observations and discoveries are connected. At times, I must say, I was often worried about the direction of my research and experienced intense moments of discouragement. Each brief eureka moment was balanced by years of dedicated and often difficult work. However, two things propelled me forward: the idea that I could help people and the excitement of discovery. My perseverance was encouraged enormously by mentors, students, collaborative colleagues, and good luck.

I first became interested in applying science to diseases at an early age, growing up on a small chicken farm, in what was then rural New Jersey. By chance I read two books that launched me on my journey: The Autobiography of Benjamin Franklin and Microbe Hunters by Paul de Kruif. These authors inspired me to dream that although I came from a humble beginning, I might live an original life of creativity and discovery.

As I did the monotonous chores on...


  1. 1.
    Cerami A, Reich E, Ward DC, Goldberg IH. (1967) The interaction of actinomycin with DNA: requirement for the 2-amino group of purines. Proc. Natl. Acad. Sci. U. S. A. 57:1036–42.CrossRefGoogle Scholar
  2. 2.
    Klett RP, Cerami A, Reich E. (1968). Exonuclease VI, a new nuclease activity associated with E. coli DNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 60:943–50.CrossRefGoogle Scholar
  3. 3.
    Cerami A, Manning JM. (1971). Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro. Proc. Natl. Acad. Sci. U. S. A. 68:1180–3.CrossRefGoogle Scholar
  4. 4.
    Gillette PN, Peterson CM, Lu YS, Cerami A. (1974) Sodium cyanate as a potential treatment for sickle-cell disease. N. Engl. J. Med. 290:654–60.CrossRefGoogle Scholar
  5. 5.
    Koenig RJ, Cerami A. (1975) Synthesis of hemoglobin AIc in normal and diabetic mice: potential model of basement membrane thickening. Proc. Natl. Acad. Sci. U. S. A. 72:3687–91.CrossRefGoogle Scholar
  6. 6.
    Koenig RJ, Blobstein SH, Cerami A. (1977) Structure of carbohydrate of hemoglobin A1c. J. Biol. Chem. 252:2992–7.PubMedGoogle Scholar
  7. 7.
    Koenig RJ, et al. (1976) Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus N. Engl. J. Med. 295:417–20.CrossRefGoogle Scholar
  8. 8.
    Cerami A. (2012) The unexpected pathway to the creation of the HbA1c test and the discovery of AGEs. J. Intern. Med. 271:214–26.CrossRefGoogle Scholar
  9. 9.
    Fairlamb AH, Blackburn P, Ulrich P, Chait BT, Cerami A. (1985). Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science. 227:1485–7.CrossRefGoogle Scholar
  10. 10.
    Slater AFG, et al. (1991) An iron-carboxylate bond links the heme units of malaria pigment. Proc. Natl. Acad. Sci. U. S. A. 88:325–9.CrossRefGoogle Scholar
  11. 11.
    Cerami A. (2011) The value of failure: the discovery of TNF and its natural inhibitor erythropoietin. J. Intern. Med. 269:8–15.CrossRefGoogle Scholar
  12. 12.
    Brines ML, et al. (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. U. S. A. 97:10526–31.CrossRefGoogle Scholar
  13. 13.
    Brines M, et al. (2004) Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc. Natl. Acad. Sci. U. S. A. 101:14907–12.CrossRefGoogle Scholar
  14. 14.
    Brines M, et al. (2008) Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc. Natl. Acad. Sci. U. S. A. 105:19025–30.CrossRefGoogle Scholar
  15. 15.
    Brines M, Cerami A. (2012) The receptor that tames the innate immune response. Mol. Med. 18:486–96.CrossRefGoogle Scholar
  16. 16.
    Dahan A, et al. (2013) ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density. Mol. Med. 19:334–45.CrossRefGoogle Scholar

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Authors and Affiliations

  1. 1.Araim PharmaceuticalsTarrytownUSA

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