Discovery of Tumor Necrosis Factor (TNF) and Identification of the Potential of Anti-TNF Antibodies in Dr. Cerami’s Laboratory
The beginning of my exciting journey for this work began in 1978 when I was a postdoctoral fellow at Columbia University and attended a lecture at Grand Rounds by a young professor from the Rockefeller University named Anthony Cerami. His topic was the identification of a new test for measuring glucose control in diabetes patients over a 1- to 2-month period. He and Ronald Koenig, a graduate student in his laboratory, had discovered that glucose could slowly react with hemoglobin in red cells of mice and humans to form a minor hemoglobin called hemoglobin A1c (Hb A1c). They showed that the amount of Hb A1ccompared with the parent molecule Hb A could be used as an integrator of blood glucose over the previous 1–2 months. This test has gone on to be the major measure of diabetic control as well as diagnostic for identifying patients with diabetes throughout the world. I was impressed with the rational way they went about proving the validity of the test, which could be used to...
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