Molecular Medicine

, Volume 20, Supplement 1, pp S17–S19 | Cite as

Discovery of Tumor Necrosis Factor (TNF) and Identification of the Potential of Anti-TNF Antibodies in Dr. Cerami’s Laboratory

  • Masanobu Kawakami

The beginning of my exciting journey for this work began in 1978 when I was a postdoctoral fellow at Columbia University and attended a lecture at Grand Rounds by a young professor from the Rockefeller University named Anthony Cerami. His topic was the identification of a new test for measuring glucose control in diabetes patients over a 1- to 2-month period. He and Ronald Koenig, a graduate student in his laboratory, had discovered that glucose could slowly react with hemoglobin in red cells of mice and humans to form a minor hemoglobin called hemoglobin A1c (Hb A1c). They showed that the amount of Hb A1ccompared with the parent molecule Hb A could be used as an integrator of blood glucose over the previous 1–2 months. This test has gone on to be the major measure of diabetic control as well as diagnostic for identifying patients with diabetes throughout the world. I was impressed with the rational way they went about proving the validity of the test, which could be used to...

Copyright information

© The Author(s) 2014

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it.

The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this license, visit (

Authors and Affiliations

  1. 1.Nerima Hikarigaoka HospitalTokyoJapan
  2. 2.Saitama Medical CenterJichi Medical UniversitySaitamaJapan

Personalised recommendations