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Molecular Medicine

, Volume 20, Issue 1, pp 427–434 | Cite as

The Role of Estrogen Receptor β in Prostate Cancer

  • Paraskevi Christoforou
  • Panagiotis F. Christopoulos
  • Michael Koutsilieris
Review Article

Abstract

Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function of the prostate gland, estrogen receptor β (ERβ) is involved in the differentiation of prostatic epithelial cells and numerous antiproliferative actions on prostate cancer cells. However, ERβ splice variants have been associated with prostate cancer initiation and progression mechanisms. ERβ is promising as an anticancer therapy and in the prevention of prostate cancer. Herein, we review the recent experimental findings of ERβ signaling in the prostate.

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Authors and Affiliations

  • Paraskevi Christoforou
    • 1
  • Panagiotis F. Christopoulos
    • 1
  • Michael Koutsilieris
    • 1
  1. 1.Department of Experimental Physiology, Medical SchoolNational & Kapodistrian University of AthensGoudi-AthensGreece

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