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Molecular Medicine

, Volume 17, Issue 1–2, pp 134–143 | Cite as

Selenium and Vitamin E for Prostate Cancer: Post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) Status

  • Mark C. Ledesma
  • Brittney Jung-Hynes
  • Travis L. Schmit
  • Raj Kumar
  • Hasan Mukhtar
  • Nihal Ahmad
Review Article

Abstract

Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer. Fortuitous results of clinical trials also implied a risk-reduction effect of selenium and vitamin E supplements. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), using oral selenium and vitamin E supplementation in disease-free volunteers, was designed to test a prostate cancer chemoprevention hypothesis. SELECT was terminated early because of both safety concerns and negative data for the formulations and doses given. Here, we review and discuss the studies done before and since the inception of SELECT, as well as the parameters of the trial itself. We believe that there is a lack of appropriate in vivopreclinical studies on selenium and vitamin E despite many promising in vitrostudies on these agents. It seems that the most effective doses and formulations of these agents for prostate cancer chemoprevention have yet to be tested. Also, improved understanding of selenium and vitamin E biology may facilitate the discovery of these doses and formulations.

Notes

Acknowledgments

This work was partially supported by National Institutes of Health grants R01CA114060 and 1R01AR059130 (to N Ahmad) and T32ES007015 (training grant; predoctoral traineeship to TL Schmit).

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Copyright information

© The Feinstein Institute for Medical Research 2011

Authors and Affiliations

  • Mark C. Ledesma
    • 1
  • Brittney Jung-Hynes
    • 1
    • 2
  • Travis L. Schmit
    • 1
    • 2
  • Raj Kumar
    • 3
  • Hasan Mukhtar
    • 1
    • 2
    • 4
  • Nihal Ahmad
    • 1
    • 2
    • 4
  1. 1.Department of DermatologyUniversity of WisconsinMadisonUSA
  2. 2.Molecular and Environmental Toxicology CenterUniversity of WisconsinMadisonUSA
  3. 3.Department of Basic SciencesThe Commonwealth Medical CollegeScrantonUSA
  4. 4.University of Wisconsin Carbone Cancer CenterMadisonUSA

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