Molecular Medicine

, Volume 14, Issue 1–2, pp 79–86 | Cite as

Nonviral Vector Gene Modification of Stem Cells for Myocardial Repair

  • Husnain K. Haider
  • Ibrahim Elmadbouh
  • Michel Jean-Baptiste
  • Muhammad Ashraf
Review Article


Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competing to exploit their advantages for optimal beneficial effects. The resistant nature of cardiomyocytes to gene transfection can be overcome by ex vivo delivery of therapeutic genes to the heart using genetically modified stem cells. This review article gives an overview of different vectors and delivery systems in general used for therapeutic gene delivery to the heart and provides a critical appreciation of the ex vivo gene delivery approach using genetically modified stem cells to achieve angiomyogenesis for the treatment of infarcted heart.


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Copyright information

© Feinstein Institute for Medical Research 2008

Authors and Affiliations

  • Husnain K. Haider
    • 1
  • Ibrahim Elmadbouh
    • 1
    • 2
  • Michel Jean-Baptiste
    • 2
  • Muhammad Ashraf
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of CincinnatiCincinnatiUSA
  2. 2.INSERM Unit 698, Cardiovascular RemodelingCHU Xavier Bichat-Claude BernardParisFrance

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