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Molecular Medicine

, Volume 12, Issue 11–12, pp 317–323 | Cite as

Structure and Enzymatic Functions of Human CD38

  • Hon Cheung LeeEmail author
Proceedings

Abstract

CD38 is a novel multifunctional protein that serves not only as an antigen but also as an enzyme. It catalyzes the metabolism of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate, two structurally and functionally distinct Ca2+ messengers targeting, respectively, the endoplasmic reticulum and lysosomal Ca2+ stores. The protein has recently been crystallized and its three-dimensional structure solved to a resolution of 1.9 Å. The crystal structure of a binary complex reveals critical interactions between residues at the active site and a bound substrate, providing mechanistic insights to its novel multi-functional catalysis. This article reviews the current advances in the understanding of the structural determinants that control the multiple enzymatic reactions catalyzed by CD38.

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Copyright information

© Feinstein Institute for Medical Research 2006

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of PhysiologyUniversity of Hong KongPokfulam, Hong KongChina

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