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A Sodium Ion Selective Electrode Based on a Highly Lipophilic Monensin Derivative and Its Application to the Measurement of Sodium Ion Concentrations in Serum

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Abstract

Five kinds of monensin derivatives were synthesized by chemical modifications of the natural carboxylic polyether antibiotic monensin. Their usefulness as active compounds (Na+-ionophores) for Na+-selective poly(vinyl chloride)(PVC)-matrix membrane electrodes was examined. The electrodes based on monensin ester derivatives exhibited high Na+-selectivity. Among them, the electrode based on the highly lipophilic monensin dodecyl ester (log K0 (partition constant)=8.7) had enough Na+-selectivity to determine the Na+-concentration in serum (log KpotNak=−1.1, log KpotNa Mg=−4.0 and log KpotNa Ca=—3.6); the electrode gave a Nernstian response (59.0mV/pNa) ranging from 5×10-6 to 1 M Na+. The response potential of this electrode to a 0.1 MNa+ solution drifted within ±0.01 mV/h. The values of the Na+-concentration in artificial and real serum samples were successfully determined with the monensin dodecyl ester-based electrode using düsodecylphthalate as the electrode membrane solvent.

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Authors and Affiliations

  1. Department of Applied Chemistry, Keio University, Hiyoshi, Yokohama, 223, Japan

    Koji Tohda, Koji Suzuki, Nobutaka Kosuge, Hitoshi Nagashima, Kazuhiko Watanabe, Hidenari Inoue & Tsuneo Shirai

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  1. Koji Tohda
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  2. Koji Suzuki
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  3. Nobutaka Kosuge
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  4. Hitoshi Nagashima
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  5. Kazuhiko Watanabe
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  6. Hidenari Inoue
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  7. Tsuneo Shirai
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Tohda, K., Suzuki, K., Kosuge, N. et al. A Sodium Ion Selective Electrode Based on a Highly Lipophilic Monensin Derivative and Its Application to the Measurement of Sodium Ion Concentrations in Serum. ANAL. SCI. 6, 227–232 (1990). https://doi.org/10.2116/analsci.6.227

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  • DOI: https://doi.org/10.2116/analsci.6.227

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