Abstract
The laser two-photon ionization technique was applied to reversed-phase high performance liquid chromatography by using a free-falling jet detector (20 nl). Methanol, acetonitrile and a mixture of acetonitrile-water (90:10) were used in the mobile phase. The dependences of the detection limit on such experimental parameters as the electrode spacing and applied voltage were measured. The best detection limit was obtained at 0.5 mm spacing and at 60 V for acetonitrile. Although these solvents showed similar leakage currents, acetonitrile gave the best detection limit. The detection limit was 60 pg for pyrene, comparable with or better than that obtained by a UV absorption detector.
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References
E. Voigtman, A. Jurgensen and J. D. Winefordner, Anal. Chem., 53, 1921 (1981).
E. Voigtman and J. D. Winefordner, Anal. Chem., 54, 1834 (1982).
S. Yamada, K. Kano and T. Ogawa, Bunseki Kagaku, 31, E247 (1982)
S. Yamada, A. Hino, K. Kano and T. Ogawa, Anal. Chem., 55, 1914 (1983).
S. Yamada, N. Sato, H. Kawazumi and T. Ogawa, Anal. Chem., 59, 2719 (1987)
N. Sato, S. Yamada and T. Ogawa, Anal. Sci., 3, 109 (1987).
S. Yamada and T. Ogawa, Prog. Analyt. Spectrosc., 9, 429 (1986).
E. Voigtman and J. D. Winefordner, J. Liq. Chromatogr., 5, 2113 (1982); 6, 1275 (1983).
E. Voigtman and J. D. Winefordner, Talanta, 30, 75 (1983).
A. Berthod, T. Mellone, E. Voigtman and J. D. Winefordner, Anal. Sci., 3, 405 (1987).
S. Yamada, A. Hino and T. Ogawa, Anal. Chim. Acta, 156, 273 (1984).
A. Hino, S. Yamada, T. Nagamura and T. Ogawa, Bunseki Kagaku, 33, 393 (1984).
S. Yamada, C. Sakane and T. Ogawa, Talanta, 34, 461 (1987).
H. Kawazumi, T. Matsumoto, N. Sato, S. Yamada and T. Ogawa, Anal. Sci., 4, 191 (1988).
S. Folestad, L. Johnson, B. Josefsson and B. Galle, Anal. Chem., 54, 925 (1982).
S. Yamada, S. Yoshida, K. Nakashima, H. Kawazumi, T. Nagamura and T. Ogawa, Eng. Sci. Repts. Kyushu Univ. 9, 15 (1987)
S. Yamada, S. Yoshida, N. Sato, H. Kawazumi and T. Nagamura, Rev. Laser Eng., 15, 1067 (1987).
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Ogawa, T., Matsumoto, T., Kawazumi, H. et al. Laser Photoionization Detector for Reversed-Phase High Performance Liquid Chromatography. ANAL. SCI. 4, 473–476 (1988). https://doi.org/10.2116/analsci.4.473
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DOI: https://doi.org/10.2116/analsci.4.473