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Acoustic Sensing Based on Density Shift of Microspheres by Surface Binding of Gold Nanoparticles

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Abstract

Herein, we propose a concept for sensing based on density changes of microparticles (MPs) caused by a biochemical reaction. The MPs are levitated by a combined acoustic-gravitational force at a position determined by the density and compressibility. Importantly, the levitation is independent of the MPs sizes. When gold nanoparticles (AuNPs) are bound on the surface of polymer MPs through a reaction, the density of the MPs dramatically increases, and their levitation position in the acoustic-gravitational field is lowered. Because the shift of the levitation position is proportional to the number of AuNPs bound on one MP, we can determine the number of molecules involved in the reaction. The avidinbiotin reaction is used to demonstrate the effectiveness of this concept. The number of molecules involved in the reaction is very small because the reaction space is small for an MP; thus, the method has potential for highly sensitive detection.

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Acknowledgments

This work was supported by a Grant-in-Aid for Challenging Exploratory Research from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Chemistry, Tokyo Institute of Technology, Meguro, Tokyo, 152-8551, Japan

    Akihisa Miyagawa, Yoshinori Inoue, Makoto Harada & Tetsuo Okada

  2. Department of Applied Chemistry, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, 470-0392, Japan

    Yoshinori Inoue

Authors
  1. Akihisa Miyagawa
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  2. Yoshinori Inoue
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  3. Makoto Harada
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  4. Tetsuo Okada
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Correspondence to Tetsuo Okada.

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Miyagawa, A., Inoue, Y., Harada, M. et al. Acoustic Sensing Based on Density Shift of Microspheres by Surface Binding of Gold Nanoparticles. ANAL. SCI. 33, 939–944 (2017). https://doi.org/10.2116/analsci.33.939

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  • DOI: https://doi.org/10.2116/analsci.33.939

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