Abstract
The intraparticle diffusion of a fluorescent dye in single microparticles in an aqueous solution was analyzed using fluorescence recovery after photobleaching, with a confocal fluorescence microscope. The fluorescence depth profile of single microparticles, and the fluorescence recovery at the particle center, were measured; further, the intraparticle diffusion coefficient was determined through simulations of three-dimensional diffusion in the respective microparticles. The intraparticle diffusion of coumarin 102 in octadecylsilyl silica gel was limited by the surface diffusion.
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Acknowledgments
The authors would like to thank the Chemical Analysis Division and Open Facility, Research Facility Center for Science and Technology, University of Tsukuba, for allowing us to use the confocal fluorescence microscope (Olympus, FV 1000-D).
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Sato, T., Hata, K. & Nakatani, K. Mass Transfer in Mesoporous Microparticles Studied by Confocal Fluorescence Recovery after Photobleaching. ANAL. SCI. 33, 647–650 (2017). https://doi.org/10.2116/analsci.33.647
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DOI: https://doi.org/10.2116/analsci.33.647