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Determination of a N-Nitrosodimethylamine Precursor in Water Using Ultra-high Performance Liquid Chromatography–Tandem Mass Spectrometry

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Abstract

1,1,5,5-Tetramethylcarbohydrazide (TMCH) is the main precursor of N-nitrosodimethylamine upon ozonation in the Yodo River basin, Japan. This study was performed to develop an analytical method for TMCH using solid-phase extraction with ultra-high performance liquid chromatography–tandem mass spectrometry. TMCH is hydrophilic and a tertiary amine derivative, so Oasis® MCX cartridges were used as solid-phase cartridges. The recoveries of TMCH in tap and river waters as well as secondary effluent from a sewage treatment plant ranged from 75 to 94%. The limit of quantification of TMCH was 4 ng L−1. The source of TMCH in the Yodo River basin was found to be effluent from one sewage treatment plant. The concentrations were < 4 ng L− in raw water from water purification plants in regions other than the Yodo River basin, indicating that TMCH was used specifically in the basin.

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Acknowledgments

The authors thank Dr. Shinya Echigo (Kyoto University, Japan) and the staff of water utilities for sample collection. This study was financially supported in part by CREST of the Japan Science and Technology Agency and a research grant from the Ministry of Health, Labour and Welfare, Japan (H25-KenkiIppan-007).

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Authors and Affiliations

  1. Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0197, Japan

    Koji Kosaka, Mari Asami & Keiko Ohkubo

  2. National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0197, Japan

    Michihiro Akiba

Authors
  1. Koji Kosaka
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  2. Mari Asami
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  3. Keiko Ohkubo
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  4. Michihiro Akiba
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Correspondence to Koji Kosaka.

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Kosaka, K., Asami, M., Ohkubo, K. et al. Determination of a N-Nitrosodimethylamine Precursor in Water Using Ultra-high Performance Liquid Chromatography–Tandem Mass Spectrometry. ANAL. SCI. 31, 769–772 (2015). https://doi.org/10.2116/analsci.31.769

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