Abstract
Microfluidics minimize the amounts of reagents and generate less waste. While microdevices are commonly single-sided, producing a substrate with microchannels on multiple surfaces would increase their usefulness. Herein, a polymethymethacrylate substrate incorporating microchannel structures on two sides was sandwiched between two polydimethylsiloxane sheets to create a multi-analysis device, which was used for the spectrophotometric analysis of the ferrous ion (Fe2+) and the ferric ion (Fe3+), by utilizing colorimetric detection. To monitor the signals from both channel networks, dual optical sensors were integrated into the system. The linear ranges for Fe2+ and Fe3+ analyses were 0.1–20 mg L−1 (R2 = 0.9988) and 1.0–40 mg L−1 (R2 = 0.9974), respectively. The detection limits for Fe2+ and Fe3+ were 0.1 and 0.5 mg L−1, respectively. The percent recoveries of Fe2+ and Fe3+ were 93.5–104.3 with an RSD < 8%. The microdevice demonstrated capabilities for simultaneous analysis, low waste generation (7.2 mL h−1), and high sample throughput (180 h−1), making it ideal for greener analytical chemistry applications.
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Acknowledgments
This work was supported by Thailand Research Funds (MRG 5380237), Thammasat University and Office of the Higher Education Commission (under the Higher Education Research Promotion, the National Research University Project of Thailand). The authors would like to acknowledge the Department of Chemistry at Thammasat University for facility and laboratory support throughout this research.
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Youngvises, N., Thanurak, P., Chaida, T. et al. Double-sided Microfluidic Device for Speciation Analysis of Iron in Water Samples: Towards Greener Analytical Chemistry. ANAL. SCI. 31, 365–370 (2015). https://doi.org/10.2116/analsci.31.365
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DOI: https://doi.org/10.2116/analsci.31.365