Skip to main content
SpringerLink
Log in

Small Animal Imaging with Hyperpolarized 129Xe Magnetic Resonance

  • Reviews
  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

High-sensitivity nuclear magnetic resonance (NMR) of gaseous atoms realized by using a hyperpolarization technique is an attractive research tool used in a wide range of areas, such as physics, chemistry, material science and biomedical imaging. One of the most promising applications of this technology is the use as a noninvasive diagnostic tool for pulmonary diseases, where hyperpolarized (HP) noble gases, 3He and 129Xe, play a role as gaseous (i.e. inhalable) contrast agents of magnetic resonance imaging (MRI). During the last two decades, lung MRI with HP gases has become widely applicable from mouse to human. In this review we present a brief overview of recent progress made by our group in the development of HP 129Xe MR measurements, while focusing on the methodology for probing pulmonary dysfunctions in mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

9 References

  1. C. J. A. van Echteld and N. Beckmann, J. Pharmacol. Exp. Ther., 2011, 337, 335.

    Article  PubMed  CAS  Google Scholar 

  2. T. G. Walker and W. Happer, Rev. Mod. Phys., 1997, 69, 629.

    Article  CAS  Google Scholar 

  3. M. S. Albert, G. D. Cates, B. Driehuys, W. Happer, B. Saam, C. S. Springer Jr., and A. Wishinia, Nature, 1994, 370, 199.

    Article  CAS  PubMed  Google Scholar 

  4. B. Driehuys, G. D. Cates, E. Miron, K. Sauer, D. K. Walter, and W. Happer, Appl. Phys. Lett., 1996, 69, 1668.

    Article  CAS  Google Scholar 

  5. I. C. Ruset, S. Ketel, and F. W. Hersman, Phys. Rev. Lett., 2006, 96, 053002.

    Article  CAS  PubMed  Google Scholar 

  6. P. Nikolaou, A. M. Coffey, L. L. Walkup, B. M. Gust, N. Whiting, H. Newton, S. Barcus, I. Muradyan, M. Dabaghyan, G. D. Moroz, M. S. Rosen, S. Patz, M. J. Barlow, E. Y. Chekmenev, and B. M. Goodson, Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 14150.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. S. B. Fain, F. R. Korosec, J. H. Holmes, R. O’Halloran, R. L. Sorkness, and T. M. Grist, J. Magn. Reson. Imaging, 2007, 25, 910.

    Article  PubMed  Google Scholar 

  8. J. P. Mugler III and T. A. Altes, J. Magn. Reson. Imaging, 2013, 37, 313.

    Article  Google Scholar 

  9. D. M. L. Lilburn, G. E. Pavlovskaya, and T. Meersmann, J. Magn. Reson., 2013, 229, 173.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. N. Beckmann, R. Kneuer, H-U. Gremlich, H. Karmouty- Quintana, F X. Blé, and M. Müller, NMR Biomed., 2007, 20, 154.

    Article  PubMed  Google Scholar 

  11. J. Fukutomi, E. Suzuki, T. Shimizu, A. Kimura, and H. Fujiwara, J. Magn. Reson., 2003, 160, 26.

    Article  CAS  PubMed  Google Scholar 

  12. H. Imai, J. Fukutomi, A. Kimura, and H. Fujiwara, Concepts Magn. Reson., Part B, 2008, 33B, 192.

  13. B. C. Anger, G. Schrank, A. Schoeck, K. A. Butler, M. S. Solum, R. J. Pugmire, and B. Saam, Phys. Rev. A, 2008, 78, 043406.

    Article  CAS  Google Scholar 

  14. H. E. Möller, Z. I. Cleveland, and B. Driehuys, J. Magn. Reson., 2011, 212, 109.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. C. J. Jameson, A. K. Jameson, and J. K. Hwang, J. Chem. Phys., 1988, 89, 4074.

    Article  CAS  Google Scholar 

  16. B. T. Chen, A. T. Yordanov, and G. A. Johnson, Magn. Reson. Med., 2005, 53, 69.

    Article  PubMed  Google Scholar 

  17. J. Nouls, M. Fanarjian, L. Hedlund, and B. Driehuys, Concepts Magn. Reson., Part B, 2011, 39B, 78.

  18. M. Zurek and Y. Crémillieux, in “In vivo NMR Imaging, Methods in Molecular Biology”, ed. L. Schroder and C. Faber, 2011, Chap. 4, Springer Science+Business Media, LLC, New York, 459.

  19. K. Mosbah, V. Stupar, Y. Berthezène, N. Beckmann, and Y. Crémillieux, Magn. Reson. Med., 2010, 63, 1669.

    Article  PubMed  Google Scholar 

  20. S. C. Cullen and E. G. Gross, Science, 1951, 113, 580.

    Article  CAS  PubMed  Google Scholar 

  21. B. M. Goodson, J. Magn. Reson., 2002, 155, 157.

    Article  CAS  PubMed  Google Scholar 

  22. M. Narazaki, A. Kimura, T. Wakayama, H. Imai, and H. Fujiwara, Magn. Reson. Med. Sci., 2011, 10, 149.

    Article  CAS  PubMed  Google Scholar 

  23. H. Imai, A. Kimura, T. Ito, and H. Fujiwara, Eur. J. Radiol., 2010, 73, 196.

    Article  PubMed  Google Scholar 

  24. K. Scheffler and S. Lehnhardt, Eur. Radiol., 2003, 13, 2409.

    Article  PubMed  Google Scholar 

  25. F. Imai, R. Kashiwagi, H. Imai, S. Iguchi, A. Kimura, and H. Fujiwara, Magn. Reson. Med. Sci., 2011, 10, 33.

    Article  PubMed  Google Scholar 

  26. M. Lustig, D. Donoho, and J. M. Pauly, Magn. Reson. Med., 2007, 58, 1182.

    Article  PubMed  Google Scholar 

  27. M. Narazaki, T. Wakayama, H. Imai, A. Kimura, and H. Fujiwara, Magn. Reson. Med. Sci., 2006, 5, 119.

    Article  CAS  PubMed  Google Scholar 

  28. J. P. Butler, R. W. Mair, D. Hoffmann, M. I. Hrovat, R. A. Rogers, G. P. Topulos, R. L. Walsworth, and S. Patz, J. Phys.: Condens. Matter, 2002, 14, L297.

  29. S. Patz, I. Muradyan, M. I. Hrovat, M. Dabaghyan, G. R. Washko, H. Hatabu, and J. P. Butler, New J. Phys., 2011, 13, 015009.

    Article  CAS  Google Scholar 

  30. H. Imai, A. Kimura, S. Iguchi, Y. Hori, S. Masuda, and H. Fujiwara, Magn. Reson. Med., 2010, 64, 929.

    Article  PubMed  Google Scholar 

  31. K. Ruppert, J. F. Mata, J. R. Brookeman, K. D. Hagspiel, and J. P. Mugler III, Magn. Reson. Med., 2004, 51, 676.

    Article  PubMed  Google Scholar 

  32. H. Imai, A. Kimura, Y. Hori, S. Iguchi, T. Kitao, E. Okubo, T. Ito, T. Matsuzaki, and H. Fujiwara, NMR Biomed., 2011, 24, 1343.

    Article  PubMed  Google Scholar 

  33. J. P. Dugas, J. R. Garbow, D. K. Kobayashi, and M. S. Conradi, Magn. Reson. Med., 2004, 52, 1310.

    Article  CAS  PubMed  Google Scholar 

  34. M. Ishii, K. Emami, Y. Xin, A. Barulic, C. J. Kotzer, G. A. Logan, E. Chia, J. P. MacDuffine-Woodburn, J. Zhu, S. Pickup, N. Kuzma, S. Kadlecek, P. L. Podolin, and R. Rizi, J. Appl. Physiol., 2012, 112, 135.

    Article  PubMed  Google Scholar 

  35. B. Driehuys, J. Walker, J. Pollaro, G. P. Cofer, N. Mistry, D. Schwartz, and G. A. Johnson, Magn. Reson. Med., 2007, 58, 893.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. A. C. Thomas, S. S. Kaushik, J. Nouls, E. N. Potts, D. M. Slipetz, W. M. Foster, and B. Driehuys, J. Appl. Physiol., 2012, 112, 1437.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. L. E. Olsson, A. Smailagic, P-O. Önnervik, and P. D. Hockings, J. Magn. Reson. Imaging, 2009, 29, 977.

    Article  PubMed  Google Scholar 

  38. R. T. Branca, Z. I. Cleveland, B. Fubara, C. S. Kumar, R. R. Maronpot, C. Leuschner, W. S. Warren, and B. Briehuys, Proc. Natl. Acad. Sci. U. S. A., 2010, 107, 3693.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Y. Hori, A. Kimura, T. Wakayama, M. Kitamoto, F. Imai, H. Imai, and H. Fujiwara, Magn. Reson. Med. Sci., 2009, 8, 73.

    Article  PubMed  Google Scholar 

  40. S. Iguchi, H. Imai, Y. Hori, J. Nakajima, A. Kimura, and H. Fujiwara, Magn. Reson. Med., 2013, 70, 207.

    Article  CAS  PubMed  Google Scholar 

  41. S. Tetsumoto, Y. Takeda, H. Imai, A. Kimura, Y. Jin, K. Nakanishi, Y. Maeda, H. Kuhara, K. Tsujino, T. Iwasaki, H. Shigeta, Y. Kondo, M. Ito, T. Minami, H. Hirata, R. Takahashi, S. Kohmo, I. Nagatomo, K. Inoue, H. Kida, T. Kijima, I. Tachibana, N. Maeda, T. Funahashi, I. Shimomura, H. Fujiwara, and A. Kumanogoh, Am. J. Respir. Cell Mol. Biol., 2013, 49, 592.

    Article  CAS  PubMed  Google Scholar 

  42. K. Ruppert, J. R. Brookeman, K. D. Hagspiel, B. Driehuys, and J. P. Mugler III, NMR Biomed., 2000, 13, 220.

    Article  CAS  PubMed  Google Scholar 

  43. S. Månsson, J. Wolber, B. Driehuys, P. Wollmer, and K. Golman, Magn. Reson. Med., 2003, 50, 1170.

    Article  PubMed  Google Scholar 

  44. N. Abdeen, A. Cross, G. Cron, S. White, T. Rand, D. Miller, and G. Santyr, Magn. Reson. Med., 2003, 50, 1170.

    Article  Google Scholar 

  45. M. S. Freeman, Z. I. Cleveland, Y. Qi, and B. Driehuys, Magn. Reson. Med., 2013, 70, 1192.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. S. Patz, W. Hersman, I. Muradyan, M. I. Hrovat, I. C. Ruset, S. Ketel, F. Jacobson, G. P. Topulos, H. Hatabu, and J. P. Butler, Eur. J. Radiol., 2007, 64, 335.

    Article  PubMed  PubMed Central  Google Scholar 

  47. S. Patz, I. Muradyan, M. I. Hrovat, I. C. Ruset, G. P. Topulos, S. D. Covrig, E. Federick, H. Hatabu, W. Hersman, and J. P. Butler, Acad. Radiol., 2008, 15, 713.

    Article  PubMed  PubMed Central  Google Scholar 

  48. B. Driehuys, G. P. Cofer, J. Pollaro, J. B. Mackel, L. W. Hedlund, and G. A. Johnson, Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 18278.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  49. T. Wakayama, M. Narazaki, A. Kimura, and H. Fujiwara, Magn. Reson. Med. Sci., 2008, 7, 65.

    Article  PubMed  Google Scholar 

  50. T. Wakayama, M. Kitamoto, T. Ueyama, H. Imai, M. Narazaki, A. Kimura, and H. Fujiwara, J. Magn. Reson. Imaging, 2008, 27, 777.

    Article  PubMed  Google Scholar 

  51. Z. I. Cleveland, G. P. Cofer, G. Metz, D. Beaver, J. Nouls, S. S. Kaushik, M. Kraft, J. Wolber, K. T. Kelly, H. P. McAdams, and B. Driehuys, PLoS One, 2010, 5, e12192.

  52. J. P. Mugler III, T. A. Altes, I. C. Ruset, I. M. Dregely, J. F. Mata, G. W. Miller, S. Ketel, J. Ketel, F. W. Hersman, and K. Ruppert, Proc. Natl. Acad. Sci. U. S. A., 2010, 107, 21707.

    Article  Google Scholar 

  53. K. Qing, K. Ruppert, Y. Jiang, J. F. Mata, G. W. Miller, Y. M. Shim, C. Wang, I. C. Ruset, F. W. Hersman, T. A. Altes, and J. P. Mugler III, J. Magn. Reson. Imaging, 2013, in press.

  54. J. E. Holmes and G. M. Bydder, Radiography, 2005, 11, 163.

    Article  Google Scholar 

  55. K. Saito, A. Kimura, and H. Fujiwara, Magn. Reson. Imaging, 2003, 21, 401.

    Article  CAS  PubMed  Google Scholar 

  56. Y. Kawata, Y. Adachi, S. Haga, J. Fukutomi, H. Imai, A. Kimura, and H. Fujiwara, Anal. Sci., 2007, 23, 1397.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Systems Informatics, Department of Systems Science, Graduate School of Informatics, Kyoto University, 606-8501, Yoshida-honmachi, Sakyo, Kyoto, Japan

    Hirohiko Imai & Atsuomi Kimura

  2. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, 565-0871, Suita, Osaka, Japan

    Hideaki Fujiwara

Authors
  1. Hirohiko Imai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsuomi Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hideaki Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hirohiko Imai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Imai, H., Kimura, A. & Fujiwara, H. Small Animal Imaging with Hyperpolarized 129Xe Magnetic Resonance. ANAL. SCI. 30, 157–166 (2014). https://doi.org/10.2116/analsci.30.157

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2116/analsci.30.157

Keywords

Search

Navigation