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Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device

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Abstract

Spherical molecularly imprinted polymer particles for bisphenol A (BPA-MIP) were easily prepared by using a Y-junction microfluidic device. The sizes of the obtained BPA-MIP particles were found to be 86 μm with a narrow size distribution. The binding characteristics were investigated by drawing a binding isotherm to estimate the binding constant and by switching the polarity of solvents to examine the feasibility of use as a medium for affinity chromatography. When dichloromethane was used as a solvent, BPA was strongly bound to the spherical BPA-MIP particles based on hydrogen bond formation; after switching the solvent to methanol, BPA was eluted quantitatively due to the weakening of the hydrogen bonding, suggesting that the spherical BPA-MIP particles can be applied to affinity-type solid-phase extraction for BPA. As the present method can provide a diverse range of spherical MIPs without tedious procedures, MIP-based affinity media will be able to be more readily used as pretreatment and/or purification for various fields.

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References

  1. J. S. Fritz, “Analytical Solid-phase Extraction”, 1999, Wiley-VCH, Weinheim.

  2. M.-C. Hennion, J. Chromatogr., A, 1999, 856, 3.

    Article  CAS  PubMed  Google Scholar 

  3. E. M. Thurman and M. S. Mills, “Solid-phase Extraction: Principles and Practice”, 1998, Wiley, New York.

  4. L. I. Andersson, J. Chromatogr., B, 2000, 739, 163.

    Article  CAS  Google Scholar 

  5. J. Haginaka, J. Sep. Sci., 2009, 32, 1548.

    Article  CAS  PubMed  Google Scholar 

  6. G. Wulff, Angew. Chem., Int. Ed. Engl., 1995, 34, 1812.

    Article  CAS  Google Scholar 

  7. M. Komiyama, T. Takeuchi, T. Mukawa, and H. Asanuma, “Molecular Imprinting”, 2002, Wiley-VCH, Weinheim.

  8. K. Haupt and K. Mosbach, Chem. Rev., 2000, 100, 2495.

    Article  CAS  PubMed  Google Scholar 

  9. R. A. Anderson, M. M. Ariffin, P. A. G. Cormack, and E. I. Miller, Forensic Sci. Int., 2008, 174, 40.

    Article  CAS  PubMed  Google Scholar 

  10. Y. Zhan, Y. Li, Y. Hu, G. Li, and Y. Chen, J. Chromatogr., A, 2010, 1217, 7337.

    Article  Google Scholar 

  11. J. Matsui, M. Okada, M. Tsuruoka, and T. Takeuchi, Anal. Commun., 1997, 34, 85.

    Article  CAS  Google Scholar 

  12. J. Matsui, K. Fujiwara, S. Ugata, and T. Takeuchi, J. Chromatogr., A, 2000, 889, 25.

    Article  CAS  PubMed  Google Scholar 

  13. J.-P. Lai, X.-Y. Lu, C.-Y. Lu, H.-F. Ju, and X.-W. He, Anal. Chim. Acta, 2001, 442, 105.

    Article  CAS  Google Scholar 

  14. J.-P. Lai, R. Niessner, and D. Knopp, Anal. Chim. Acta, 2004, 522, 137.

    Article  CAS  Google Scholar 

  15. R. Walsh, Q. Osmani, H. Hughes, P. Duggan, and P. McLoughlin, J. Chromatogr., B, 2011, 879, 3523.

    Article  CAS  Google Scholar 

  16. A. Kawai, S. Matsumoto, H. Kiriya, T. Oikawa, K. Hara, T. Ohkawa, T. Futami, K. Katayama, and K. Nishizawa, TOSOH Research and Technology Review, 2003, 47, 3.

  17. S. Okushima, T. Nisisako, T. Torii, and T. Higuchi, Langmuir, 2004, 20, 9905.

    Article  CAS  PubMed  Google Scholar 

  18. M. L. J. Steegmans, K. G. P. H. Schroën, and R. M. Boom, Langmuir, 2009, 25, 3396.

    Article  CAS  PubMed  Google Scholar 

  19. Z. Nie, S. Xu, M. Seo, P. C. Lewis, and E. Kumacheva, J. Am. Chem. Soc, 2005, 127, 8058.

    Article  CAS  PubMed  Google Scholar 

  20. S.-H. Kim, A. Abbaspourrad, and D. A. Weitz, J. Am. Chem. Soc., 2011, 133, 5516.

    Article  CAS  PubMed  Google Scholar 

  21. A. Kubo, H. Shinmori, and T. Takeuchi, Chem. Lett., 2006, 35, 588.

    Article  CAS  Google Scholar 

  22. S. Kitamura, T. Suzuki, S. Sanoh, R. Kohta, N. Jinno, K. Sugihara, S. Yoshihara, N. Fujimoto, H. Watanabe, and S. Ohta, Toxicol. Sci., 2005, 84, 249.

    Article  CAS  PubMed  Google Scholar 

  23. T. Ikegami, W.-S. Lee, H. Nariai, and T. Takeuchi, Anal. Bioanal. Chem., 2004, 379, 1898.

    Article  Google Scholar 

  24. T. Ikegami, W.-S. Lee, H. Nariai, and T. Takeuchi, J. Chromatogr., B, 2004, 804, 197.

    Article  CAS  Google Scholar 

  25. T. Ikegami, T. Mukawa, H. Nariai, and T. Takeuchi, Anal. Chim. Acta, 2004, 504, 131.

    Article  CAS  Google Scholar 

  26. S. Sasaki, T. Ooya, and T. Takeuchi, Polym. Chem., 2010, 1, 1684.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Graduate School of Engineering, Kobe University, 1-1 Rokkodai, 657-8501, Nada, Kobe, Japan

    Eri Takano, Fujimaru Tanaka, Tooru Ooya & Toshifumi Takeuchi

Authors
  1. Eri Takano
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  2. Fujimaru Tanaka
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  3. Tooru Ooya
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  4. Toshifumi Takeuchi
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Correspondence to Toshifumi Takeuchi.

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Takano, E., Tanaka, F., Ooya, T. et al. Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device. ANAL. SCI. 28, 457–461 (2012). https://doi.org/10.2116/analsci.28.457

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  • DOI: https://doi.org/10.2116/analsci.28.457

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