Skip to main content
SpringerLink
Log in

Application of a Disposable Screen-Printed Electrode to Depression Diagnosis for Laboratory Rats Based on Blood Serotonin Detection

  • Original Papers
  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

No exact and digital diagnostic methods for depression have been found. In this study, we prepared a 5-HT biosensor based on screen-printed electrode and applied it to a rat depression model caused by chronic unpredictable mild stress (CUMS). During CUMS, the blood 5-HT and the depression behavior of the depressed rats and the rats treated by antidepressants were recorded. The correlation coefficient of 5-HT was 0.9966 (0 – 4 × 10−6 M) on the sensor. Results demonstrated that 5-HT level of the depressed rats declined while the depression behavior was aggravated. Fluoxetine (20 mg/kg) and lentinan (10, 20 mg/kg) mildly elevated 5-HT level and slowly regulated the behavior. Mifepristone (20 mg/kg) and Rhizoma Coptidis water extract (10, 20, 100 mg/kg) quickly reversed 5-HT level and the depression behavior. This sensor can accurately test blood 5-HT and might be applied to rapid diagnosis for depression and evaluation of antidepressants effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. Karakulova, Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, 2006, 106, 52.

    PubMed  Google Scholar 

  2. K. Wu, J. Fei, and S. Hu, Anal. Biochem., 2003, 318, 100.

    Article  CAS  PubMed  Google Scholar 

  3. T. N. Wise, L. M. Arnold, and V. Maletic, CNS Spectrums, 2005, 10, 1.

    Article  Google Scholar 

  4. T. Yoshitake, J. Kehr, K. Todoroki, H. Nohta, and M. Yamaguchi, Biomed. Chromatogr., 2006, 20, 267.

    Article  CAS  PubMed  Google Scholar 

  5. N. Kato, T. Kojima, and S. Yoshiyagawa, J. Chromatogr., A, 2007, 1145, 229.

    Article  CAS  PubMed  Google Scholar 

  6. J. D. Cooper, K. E. Heppert, M. I. Davies, and S. M. Lunte, J. Neurosci. Methods, 2007, 160, 269.

    Article  CAS  PubMed  Google Scholar 

  7. R. N. Goyal, V. K. Gupta, M. Oyama, and N. Bachheti, Talanta, 2007, 72, 976.

    Article  CAS  PubMed  Google Scholar 

  8. H. Yao, S. G. Li, Y. H. Tang, Y. Chen, Y. Z. Chen, and X. H. Lin, Electrochim. Acta, 2009, 54, 4607.

    Article  CAS  Google Scholar 

  9. K. Ueda, R. Yonemoto, K. Komagoe, K. Masuda, N. Hanioka, S. Narimatsu, and T. Katsu, Anal. Chim. Acta, 2006, 565, 36.

    Article  CAS  Google Scholar 

  10. S. Miserere, S. Ledru, N. Ruille, S. Griveau, M. Boujtitab, and F. Bedioui, Electrochem. Commun., 2006, 8, 238.

    Article  CAS  Google Scholar 

  11. G. Zhao, F. Xing, and S. Deng, Electrochem. Commun., 2007, 9, 1263.

    Article  CAS  Google Scholar 

  12. M. Liu, J. Xiang, J. Zhou, and H. Ding, J. Electroanal. Chem., 2010, 640, 1.

    Article  CAS  Google Scholar 

  13. N. D. Demchuk and A. A. Shutov, Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, 2008, 108, 29.

    CAS  PubMed  Google Scholar 

  14. J. Roggenbach, B. M. Oerlinghausen, L. Franke, R. Uebelhack, S. Blank, and B. Ahrens, J. Neural Transm., 2007, 114, 479.

    Article  CAS  PubMed  Google Scholar 

  15. J. C. Alvarez, N. Gluck, A. Fallet, A. Grégoire, J. F. Chevalier, C. Advenier, and O. Spreux-Varoquaux, Psychopharmacology (Berlin, Ger.), 1999, 143, 97.

    Article  CAS  Google Scholar 

  16. D. Mück-Šeler, N. Pivac, M. Šagud, M. Jakovljevic, and P. A. Mihaljevic, Progress Neuropsychopharm Biol. Psychiatry, 2002, 26, 1235.

    Article  Google Scholar 

  17. J. C. Bernard and T. R. Robert, Neuropsychopharmacology, 2006, 31, 2793.

    Article  Google Scholar 

  18. G. E. Tafet, V. P. Idoyaga-Vargas, D. P. Abulafia, J. M. Calandria, S. S. Roffman, A. Chiovetta, and M. Shinitzky, Cogn. Affect. Behav. Neurosci., 2001, 1, 388.

    Article  CAS  PubMed  Google Scholar 

  19. Y. Edagawa, M. Smriga, N. Nishiyama, and H. Saito, Neurosci. Lett., 2001, 314, l39.

  20. V. Vetvicka and J. C. Yvin, Int. Immunopharmacol., 2004, 4, 721.

    Article  CAS  PubMed  Google Scholar 

  21. W. H. Peng, K. L. Lo, Y. H. Lee, T. H. Hung, and Y. C. Lin, Life Sci., 2007, 81, 933.

    Article  CAS  PubMed  Google Scholar 

  22. S. K. Kulkarni and A. Dhir, Eur. J. Pharm. Sci., 2008, 589, 163.

    Article  CAS  Google Scholar 

  23. A. Wesolowska and A. Nikiforuk, Eur. J. Pharm. Sci., 2008, 582, 88.

    Article  CAS  Google Scholar 

  24. J. Turkevich, P. C. Stevenson, and J. Hillier, Discussions Faraday Soc., 1951, 11, 55.

    Article  Google Scholar 

  25. J. Y. Tang, Y. S. Zeng, Q. G. Chen, Y. J. Qin, S. J. Chen, and Z. Q. Zhong, J. Sun Yat-sen Univ. (Med. Sci.), 2008, 29, 541.

    Google Scholar 

  26. P. Willner, Psychopharmacology, 1997, 134, 319.

    Article  CAS  PubMed  Google Scholar 

  27. H. X. Dang, Y. Chen, X. M. Liu, Q. Wang, L. Wang, W. Jia, and Y. Wang, Prog. Neuro-Psychoph., 2009, 33, 1417.

    Article  CAS  Google Scholar 

  28. B. J. Carroll and R. T. Rubin, Neuropsychopharmacology, 2005, 31, 2793.

    Article  Google Scholar 

  29. D. Mück-Šeler, N. Pivac, M. Mustapic, Z. Crncevic, M. Jakovljevic, and M. Sagud, Psychiat. Res., 2004, 127, 217.

    Article  Google Scholar 

  30. P. Willner, A. Towell, D. Sampson, S. Sophokleous, and R. Muscat, Psychopharmacology, 1987, 93, 358.

    Article  CAS  PubMed  Google Scholar 

  31. S. Bekris, K. Antonious, S. Daskas, and Z. Papadopoulous-Daifoti, Behav. Brain Res., 2005, 161, 45.

    Article  CAS  PubMed  Google Scholar 

  32. N. M. Lind, M. Vinther, R. P. Hemmingsen, and A. K. Hansen, J. Neurosci. Methods, 2005, 143, 123.

    Article  PubMed  Google Scholar 

  33. W. L. Mai, Q. Wang, X. M. Liu, Y. H. Li, S. G. Chen, L. W. Wang, Y. F. Zhu, and Z. Q. Feng, Acta Lab Anim. Sci. Sin., 2008, 16, 570.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, South-Central University for Nationalities, 430074, Wuhan, P. R. China

    Min Liu

  2. Department of Pharmacy, Wuhan University, 430072, Wuhan, P. R. China

    Jiajie Hu, Tian Ma, Shi Wang & Hong Ding

Authors
  1. Min Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiajie Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tian Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shi Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hong Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hong Ding.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, M., Hu, J., Ma, T. et al. Application of a Disposable Screen-Printed Electrode to Depression Diagnosis for Laboratory Rats Based on Blood Serotonin Detection. ANAL. SCI. 27, 839–843 (2011). https://doi.org/10.2116/analsci.27.839

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2116/analsci.27.839

Search

Navigation