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Determination of Phthalates and Adipate in Physiological Saline Solutions by Solid-Phase Microextraction and Gas Chromatography

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Abstract

This study describes an analytical methodology developed for determination of phthalate esters (di-n-butyl, butylbenzyl and di-2-ethylhexyl phthalate) and adipate (di-n-ethylhexyl adipate) by solid-phase microextraction (SPME) and gas chromatography in normal saline solutions and, in bi-distilled water used to reconstitute medicines. An 85-μm-polyacrylate SPME fiber was selected and used in all analyses. The parameters affecting extraction efficiency were simultaneously optimized, firstly by means of a two-level full factorial design including a center point and subsequently through a Doehlert design for two-variables. Satisfactory detection limits in the range of 0.18 to 0.75 μg L−1 and excellent precision, with relative standard deviation values being lower than 15.1% (n = 6), were obtained. Relative sensitivities of between 72.3 and 124.3% were obtained.

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Authors and Affiliations

  1. Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Marcel Silveira dos Santos, Dilma Budziak, Edmar Martendal & Eduardo Carasek

Authors
  1. Marcel Silveira dos Santos
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  2. Dilma Budziak
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  3. Edmar Martendal
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  4. Eduardo Carasek
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Corresponding author

Correspondence to Eduardo Carasek.

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Santos, M.S., Budziak, D., Martendal, E. et al. Determination of Phthalates and Adipate in Physiological Saline Solutions by Solid-Phase Microextraction and Gas Chromatography. ANAL. SCI. 25, 865–868 (2009). https://doi.org/10.2116/analsci.25.865

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  • DOI: https://doi.org/10.2116/analsci.25.865

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