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Determination and Pharmacokinetics of a New Diorganotin(IV) Complex Dibutyldi(4-chlorobenzohydroxamato)tin(IV) in Rat Plasma by a High Performance Liquid Chromatographic Method

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Abstract

Dibutyldi(4-chlorobenzohydroxamato)tin(IV) is a new diorganotin(IV) arylhydroxamate complex with 4-chloro-benzohydroxamic acid as ligand which shows high in vivo and in vitro antitumor activity. A high performance liquid chromatographic (HPLC) method using a Diamonsil ODS column was first validated in the pharmacokinetic studies in rat plasma. The plasma was deproteinized with methanol that contained acetanilide as the internal standard. The mobile phase was a mixture of methanol and 0.5% trifluoroacetic acid (TFA) in water (30:70) (pH 3.0). The detection wavelength was set at 238 nm. A linear curve over the concentration range 0.1 – 25 μg/ml (r = 0.9992) was obtained. The method was used to determine the concentration–time profiles for dibutyldi(4-chlorobenzohydroxamato)tin(IV) in the plasma after a single intravenous dose of 2, 5, and 12 mg/kg to rats. The pharmacokinetics parameter calculations and modeling were carried out using the 3p97 pharmacokinetics software. A nonlinear pharmacokinetics was found in rats at doses from 2 to 12 mg/kg. The results showed that the concentration–time curves of dibutyldi(4-chlorobenzohydroxamato)-tin(IV) in rat plasma could be fitted to two-compartment model.

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Authors and Affiliations

  1. School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, 030001, People’s Republic of China

    Yunlan Li, Jinjie Liu, Yong Li & Qingshan Li

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  1. Yunlan Li
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  2. Jinjie Liu
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  3. Yong Li
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  4. Qingshan Li
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Correspondence to Qingshan Li.

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Li, Y., Liu, J., Li, Y. et al. Determination and Pharmacokinetics of a New Diorganotin(IV) Complex Dibutyldi(4-chlorobenzohydroxamato)tin(IV) in Rat Plasma by a High Performance Liquid Chromatographic Method. ANAL. SCI. 25, 699–703 (2009). https://doi.org/10.2116/analsci.25.699

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  • DOI: https://doi.org/10.2116/analsci.25.699

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