Abstract
A flow injection chemiluminescent (FI-CL) method was developed for the determination of pioglitazone HCl. It is based on the sensitizing effect of the drug on the oxidation reaction of sulfite with cerium(IV). The different experimental parameters affecting the chemiluminescence intensity, such as concentration of reagents and some physical parameters of the manifold, were carefully studied and incorporated into the procedure. The method permits the determination of 0.05 – 3.0 µg ml–1 of pioglitazone HCl with correlation coefficient r = 0.9999. The lower limit of detection (LOD) is 0.01 µg ml−1 (S/N = 2) and the lower limit of quantitation (LOQ) is 0.05 µg ml−1. The proposed method was compared with other reported methods and was found to be equally accurate and precise. It was successfully applied to the determination of the drug in pharmaceutical preparations and in biological fluids.
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J. Waugh, G. M. Keating, G. L. Plosker, S. Easthope, and D. M. Robinson, Drugs, 2006, 66, 85.
J. Chilcott, P. Tappenden, M. Lloyd, and J. P. Wight, Clin. Ther., 2001, 23, 1792.
Takeda Pharmaceutical Company Limited, Actos (pioglitazone hydrochloride) Full Prescribing Information, Osaka, Japan, (2004), http://www.actos.com/pi.pdf.
P. Sripalakit, P. Neamhom, and A. Saraphanchotiwitthaya, J. Chromatogr. , B, 2006, 843, 164.
J. D. Dai, D. J. Jin, and Y. L. Liu, Yaowu Fenxi Zazhi, 2001, 21, 36.
W. Z. Zhong and M. G. Williams, J. Pharm. Biomed. Anal., 1996, 14, 465.
W. Z. Zhong and D. B. Laking, J. Chromatogr. Biomed. Appl., 1989, 490, 377.
P. Venkatesh, T. Harisudhan, H. Choudhury, R. Mullangi, and N. R. Srinivas, Biomed. Chromatogr., 2006, 20, 1043.
Y. H. Xue, K. C. Turner, J. B. Meeker, J. Pursley, M. Arnold, and S. Unger, J. Chromatogr., B, 2003, 795, 215.
Z. J. Lin, W. Ji, D. Desai-Krieger, and L. Shum, J. Pharm. Biomed. Anal., 2003, 33, 101.
E. N. M. Ho, K. C. H. Yiu, T. S. M. Wan, B. D. Stewart, and K. L. Watkins, J. Chromatogr., B, 2004, 811, 65.
A. Gumieniczek, H. Hopkala, and A. Berecka, J. Liq. Chromatogr. Relat. Technol., 2004, 27, 2057.
A. Gumieniczek, H. Hopkala, A. Berecka, and D. Kowalczuk, J. Planar Chromatogr.—Mod. TLC, 2003, 16, 271.
B. Ravi, G. Deepak, and J. Aishwarya, J. Planar Chromatogr.—Mod. TLC, 2006, 19, 288.
T. Radhakrishna, D. Sreenivas, and G. O. Reddy, J. Pharm. Biomed. Anal., 2002, 29, 593.
B. Jamali, G. C. Theill, and L. L. Sorensen, J. Chromatogr., A, 2004, 1049, 183.
B. Jamali, I. Bjornsdottir, O. Nordfang, and S. H. Hansen, J. Pharm. Biomed. Anal., 2008, 46, 82.
G. A. E. Mostafa and A. Al-Majed, J. Pharm. Biomed. Anal., 2008, in press.
M. B. Shankar, V. D. Modi, D. A. Shah, K. K. Bhatt, R. S. Mehta, M. Geetha, and B. J. Patel, J. AOAC Int., 2005, 88, 1167.
D. G. Sankar, J. M. R. Kumar, and M. V. V. N. Reddy, Asian J. Chem., 2004, 16, 537.
I. I. Koukli, E. G. Sarantonis, and A. C. Calokerinos, Analyst, 1988, 133, 603.
M. C. S. Alonso, L. L. Zamora, and J. M. Catalayud, Anal. Chim. Acta, 2001, 437, 225.
I. I. Koukli and A. C. Calokerinos, Analyst, 1990, 115, 1553.
I. I. Koukli and A. C. Calokerinos, Anal. Chim. Acta, 1990, 236, 463.
K. Takeuchi and T. Ibusuki, Anal. Chim. Acta, 1985, 174, 359.
R. W. B. Pears and A. G. Gaydon, “The Identification of Molecular Spectra”, Chapman and Hall, 4th ed., 1976, London.
Y. Rao, Y. Tong, X. Zhang, G. Luo, and W. R. G. Baeyens, Anal. Lett., 2000, 33, 111.
F. A. Aly, N. A. Alarfaj, and A. A. Alwarthan, Talanta, 2001, 54, 715.
J. A. Ocana, M. Callejon, F. J. Barragan, and F. F. De la Rosa, Anal. Chim. Acta, 2003, 482, 105.
R. Caulcutt and R. Boddy, “Statistics for Analytical Chemists”, Chapman and Hall, 1983, London.
S. S. C. Martindale, “The Complete Drug Reference”, 2002, 33rd ed., Pharmaceutical Press, London, Chicago.
B. L. Kolte, B. B. Raut, A. A. Deo, M. A. Bagool, and D. B. Shinde, J. Chromatogr., B, 2003, 788, 37.
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Al-Arfaj, N.A., Al-Abdulkareem, E.A. & Aly, F.A. Flow-Injection Chemiluminometric Determination of Pioglitazone HCl by Its Sensitizing Effect on the Cerium-Sulfite Reaction. ANAL. SCI. 25, 401–406 (2009). https://doi.org/10.2116/analsci.25.401
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DOI: https://doi.org/10.2116/analsci.25.401