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Development of Miniaturized Hollow-fiber Assisted Liquid-phase Microextraction with in situ acyl Derivatization Followed by GC-MS for the Determination of Benzophenones in Human Urine Samples

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Abstract

A simple and highly sensitive method that involves miniaturized hollow fiber assisted liquid-phase microextraction (HF-LPME) with in situ acyl derivatization and GC-MS was developed for the determination of benzophenone (BP) and related compounds in human urine samples. The limits of detection (S/N = 3) and quantification (S/N > 10) of BPs in human urine samples are 0.01 to 0.05 and 0.05 to 0.2 ng ml−1, respectively. The average recoveries of BPs (n = 5) in human urine samples spiked with 10 and 50 ng ml−1 BPs are 93.1 to 106.7% (RSD: 1.5 to 8.4%) and 96.3 to 101.5% (RSD: 3.0 to 7.7%), respectively. When the proposed method was applied to human urine samples, BPs were detected at the sub ng ml−1 level.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, 142-8501, Shinagawa, Tokyo, Japan

    Rie Ito, Youji Koganei, Hidehiro Honda, Noriya Okanouchi, Koichi Saito & Hiroyuki Nakazawa

  2. Bio-Medical Standard Section, National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 3, 1-1-1 Umezono, 305-8563, Tsukuba, Ibaraki, Japan

    Migaku Kawaguchi

  3. Agilent Technologies, Hachioji Site, 9-1 Takakura, 192-0033, Hachioji, Tokyo, Japan

    Norihiro Sakui

Authors
  1. Rie Ito
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  2. Migaku Kawaguchi
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  3. Youji Koganei
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  4. Hidehiro Honda
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  5. Noriya Okanouchi
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  6. Norihiro Sakui
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  7. Koichi Saito
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  8. Hiroyuki Nakazawa
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Correspondence to Rie Ito.

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Ito, R., Kawaguchi, M., Koganei, Y. et al. Development of Miniaturized Hollow-fiber Assisted Liquid-phase Microextraction with in situ acyl Derivatization Followed by GC-MS for the Determination of Benzophenones in Human Urine Samples. ANAL. SCI. 25, 1033–1037 (2009). https://doi.org/10.2116/analsci.25.1033

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  • DOI: https://doi.org/10.2116/analsci.25.1033

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