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Baseline Noise and Measurement Uncertainty in Liquid Chromatography

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Abstract

The stochastic properties of baseline noise in HPLC systems with a UV photo-diode array, photo-multiplier and γ-ray detector were examined by dividing the noise into auto-correlated random process (Markov process) and an independent process (white noise). The present work focused on the effect of the stochastic noise properties on a theoretical estimation of the standard deviation (SD) of area measurements in instrumental analyses. An estimation theory, called FUMI theory (Function of Mutual Information), was taken as an example. A computer simulation of noise was also used. It was shown that the reliability (confidence intervals) of theoretical SD estimates mainly depends on the following factors: the ratio of the white noise and Markov process occurring in the baselines; the number of data points used for the estimation; the width of a target peak for which the SD is estimated.

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Authors and Affiliations

  1. Daiichi Radioisotope Laboratories, 453-1 Shimookura, Matsuo-machi, Sanmu, Chiba, 289-1592, Japan

    Akihito Kitajima & Takao Minamizawa

  2. The University of the Air, 2-11 Wakaba, Mihama, Chiba, 261-8586, Japan

    Takeshi Kashirajima

  3. School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan

    Hiroyasu Sato & Kazuo Iwaki

  4. Hayashi Pure Chemical Ind., Ltd., 3-2-12 Uchihiranomachi, Chuo, Osaka, 540-0037, Japan

    Taisuke Ueda & Yoshio Kimura

  5. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga, Shizuoka, 422-8526, Japan

    Akihito Kitajima & Toshimasa Toyo’oka

  6. National Institute of Health Sciences, 1-18-1 Kami-Yoga, Setagaya, Tokyo, 158-8501, Japan

    Tamio Maitani, Rieko Matsuda & Yuzuru Hayashi

Authors
  1. Akihito Kitajima
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  2. Takeshi Kashirajima
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  3. Takao Minamizawa
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  4. Hiroyasu Sato
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  5. Kazuo Iwaki
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  6. Taisuke Ueda
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  7. Yoshio Kimura
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  8. Toshimasa Toyo’oka
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  9. Tamio Maitani
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  10. Rieko Matsuda
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  11. Yuzuru Hayashi
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Corresponding author

Correspondence to Kazuo Iwaki.

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Kitajima, A., Kashirajima, T., Minamizawa, T. et al. Baseline Noise and Measurement Uncertainty in Liquid Chromatography. ANAL. SCI. 23, 1077–1080 (2007). https://doi.org/10.2116/analsci.23.1077

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  • DOI: https://doi.org/10.2116/analsci.23.1077

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