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Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

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Abstract

New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10-5 M to 1.0 × 10-2 M and 1.0 × 10-5 M to 1.0 × 10-2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10-5 M to 1.00 x 10-2 M and 1.0 x 10-5 M to 1.0 × 10-2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10-5 M and 5.62 × 10-6 M at 25 ± 1°C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.

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References

  1. “Martindale: The Extra Pharmacopoeia”, 33rd ed., 2002. The Pharmaceutical Press, London, 1067.

  2. M. J. Nozal, J. L. Bernal, L. Toribio, M. T. Martin, and F. J. Diez, J. Chromatogr., 2001, 919, 87.

    Article  CAS  Google Scholar 

  3. H. L. Li, S. Y. Gao, D. Jin, and G. Z. Ying, Yaowu Fexi Zazhi, 2001, 21, 434. Anal. Abstr., 2002, 64, 11G120.

    CAS  Google Scholar 

  4. G. V. Kanumula and B. Ruman, Indian Drugs, 2000, 37, 375.

    CAS  Google Scholar 

  5. J. S. Munro and T. A. Walker, J. Chromatogr., 2001, 914, 13.

    Article  CAS  Google Scholar 

  6. A. Ahmadiani and H. Amini, J. Chromatogr., B. Biomed. Appl., 2001, 751, 291.

    Article  CAS  Google Scholar 

  7. C. Ho, H. M. Haung, S. Y. Hsu, C. Y. Shaw, and B. L. Chang, Drug Dev. Ind. Pharm., 1999, 25, 379.

    Article  CAS  Google Scholar 

  8. A. Gyeresi, M. Gergely, and J. Vamos, J. Planar Chromatogr, Mod. TLC, 2000, 13, 296.

    CAS  Google Scholar 

  9. M. A. Kelly, K. D. Altria, C. Grace, and B. J. Clark, J. Chromatogr., 1998, 798, 297.

    Article  CAS  Google Scholar 

  10. T. Perez-Ruiz, L. C. Martinez, V. Tomas, E. Pravo, and R. Galera, J. Pharm. Biomed. Anal, 2002, 30, 1055.

    Article  CAS  Google Scholar 

  11. K. M. Kelani, A. A. Moustafa, M. A. Hegazy, and L. Abdel Fattah, Anal. Lett., 2002, 35, 1055.

    Article  CAS  Google Scholar 

  12. E. M. Hassan and F. Belal, J. Pharm. Biomed. Anal, 2002, 27, 31.

    Article  CAS  Google Scholar 

  13. A. K. S. Ahmad, M. A. Kawy, and M. Nebsen, Anal. Lett., 1999, 32, 1403.

    Article  CAS  Google Scholar 

  14. C. S. Sastry, S. G. Rao, J. S. Rao, and P. Y. Naidu, Anal. Lett., 1997, 30, 2377.

    Article  CAS  Google Scholar 

  15. S. Raghuveer, C. M. Srivastava, and D. K. Vatsa, Indian Drugs, 1992, 29, 480.

    CAS  Google Scholar 

  16. T. Perez-Ruiz, L. C. Martinez, V. Tomas, A. Sanz, and E. Sahuguillo, J. Pharm. Biomed. Anal, 2001, 26, 609.

    Article  CAS  Google Scholar 

  17. E. Dreassi, G. Ceramelli, P. Corti, P. L. Perruccio, and S. Lonardi, Analyst, 1996, 121, 219.

    Article  CAS  Google Scholar 

  18. T. Ozden, A. Ungormus, A. Tosun, and S. Ersan, Spectrosc. Lett., 1997, 30, 835.

    Article  CAS  Google Scholar 

  19. K. S. Agatonovic, T. Rades, V. Wu, D. Saville, and I. G. Tucker, J. Pharm. Biomed. Anal, 2001, 17

  20. K. Nikolic, B. Stankovic, and M. Bogavac, Farmazie, 1995, 50, 301.

    CAS  Google Scholar 

  21. Z. Atkosar and M. Tuncel, Acta Pharm. Jure, 1989, 31, 139.

    CAS  Google Scholar 

  22. H. Liu, C. L. Huang, and R. Xiu, Fenxi Kexue Xuebao, 2000, 16, 27. Anal. Abstr., 2000, 62, 7G135.

    Google Scholar 

  23. S. S. Badawy, A. F. Shoukry, and Y. M. Issa, Analyst, 1986, 111, 1363.

    Article  CAS  Google Scholar 

  24. R. P. Buck and E. Lindner, Pure Appl. Chem., 1994, 66, 227.

    Article  Google Scholar 

  25. R. Aubeck, C. Brauchle, and N. Hampp, Anal. Chim. Acta, 1990, 238, 405

    Article  CAS  Google Scholar 

  26. Y. Umezawa, P. Buhlmann, K. Umezawa, K. Tohda, and S. Amemiya, Pure Appl. Chem., 2000, 72, 1851.

    Article  CAS  Google Scholar 

  27. W. Qin, W. Zhang, K. P. Xiao, and M. E. Meyerhoff, Anal. Bioanal. Chem., 2003, 377, 929.

    Article  CAS  Google Scholar 

  28. M. Trojanowicz and W. Matuszewski, Anal. Chim. Acta, 1982, 138, 71.

    Article  CAS  Google Scholar 

  29. X. Yang, D. B. Hibbert, and P. W. Alexander, Anal. Chim. Acta, 1998, 372, 387.

    Article  CAS  Google Scholar 

  30. A. Shatkay, Anal. Chem., 1976, 48, 1039.

    Article  CAS  Google Scholar 

  31. “British Pharmacopoeia”, 2000, Vol. 1, Her Majesty’s Stationary Office, London.

  32. J. C. Miller and J. N. Miller, “Statistics in Analytical Chemistry”, 1994, Ellis Horwood, Chichester, England.

    Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    Yousry M. Issa, Sayed S. Badawy & Ali A. Mutair

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  1. Yousry M. Issa
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  2. Sayed S. Badawy
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  3. Ali A. Mutair
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Correspondence to Sayed S. Badawy.

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Issa, Y.M., Badawy, S.S. & Mutair, A.A. Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques. ANAL. SCI. 21, 1443–1448 (2005). https://doi.org/10.2116/analsci.21.1443

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  • DOI: https://doi.org/10.2116/analsci.21.1443

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