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Preparation of Spherical Nucleic Acid Nanoparticles Containing a Self-immolative Poly(carbamate) Core

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Abstract

We prepared a novel spherical nucleic acid, containing a core structure of self-immolative poly(carbamate) (PC), with aminobenzyl alcohol as a repeating unit, by conjugating an end-activated PC derivative with an amine-terminated oligoDNA on a solid support for PC-oligoDNA. Dynamic light-scattering measurements revealed a hydrodynamic diameter of 107 nm with a narrow size distribution. A fluorescent monomer with aminobenzyl alcohol is available for PC-oligoDNA synthesis to enhance the fluorescence emission by a domino-like disassembly of PC in response to various external stimuli.

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Acknowledgements

This work was supported by Japan Society for the Promotion of Science KAKENHI (grant number: JP17K05938).

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Authors and Affiliations

  1. Department of Materials Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, 125-8585, Japan

    Shione Fukumoto, Mami Kawade, Kazunori Kimura & Akihiko Kikuchi

  2. Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, 125-8585, Japan

    Yoshitsugu Akiyama

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  1. Shione Fukumoto
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  2. Mami Kawade
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  3. Kazunori Kimura
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  4. Yoshitsugu Akiyama
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  5. Akihiko Kikuchi
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Correspondence to Yoshitsugu Akiyama.

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Fukumoto, S., Kawade, M., Kimura, K. et al. Preparation of Spherical Nucleic Acid Nanoparticles Containing a Self-immolative Poly(carbamate) Core. ANAL. SCI. 37, 781–784 (2021). https://doi.org/10.2116/analsci.20SCN06

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  • DOI: https://doi.org/10.2116/analsci.20SCN06

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