Abstract
An ultra-sensitive analytical system that can determine the concentration of N-nitrosamines at the ng/L level without preconcentration was used to investigate the contamination, decomposition, and formation of N-nitrosodimethylamine (NDMA) and other N-nitrosamines in water samples during general analytical procedures. A preliminary experiment was performed to estimate the NDMA concentrations in ambient air. Since the air samples contained NDMA at concentrations in the range of 2.0–10.7 ng/m3, ambient air was identified as the source of NDMA contamination in water samples. We directly confirmed that the concentration of aqueous 10-ng/L NDMA samples stored in clear glass bottles decreased upon exposure to sunlight. Thus, to maintain the N-nitrosamine concentration, such samples must always be protected from sunlight during sampling. The existence of N-nitrosamines in experimental reagents, such as ranitidine and sodium hypochlorite solutions, was also confirmed, as was the formation of NDMA on an activated carbon solid-phase extraction cartridge.
Similar content being viewed by others
References
A.R. Tricker and R. Preussmann, Mutat. Res. Toxicol., 1991, 259, 277.
A. Chisvert, J.L. Benedé, M. Peirö, I. Pedron, A. Salvador, Talanta, 2017, 766, 81.
W. Altkofer, S. Braune, K. Ellendt, M. Kettl-Grömminger, G. Steiner, Mol. Nutr. Food Res., 2005, 49, 235.
W.A. Mitch, J.O. Sharp, R.R. Trussell, R.L. Valentine, L. Alvarez-Cohen, D.L. Sedlak, Environ. Eng. Sci., 2003, 20, 389
M. Sgroi, F.G.A. Vagliasindi, S.A. Snyder, P. Roccaro, Chemosphere, 2018, 797, 685.
S. Itoh, J. Japan Soc. Water Environ., 2016, 39, 187.
California Department of Public Health, NDMA and Other Nitrosamines—Drinking Water Issues, www.cdph.ca.gov/certlic/drinkingwater/Pages/NDMA.aspx.
Environment Protection and Heritage Council, National Health and Medical Research Council, Natural Resources Management Ministerial Council, "Australian Guidelines for Water Recycling Augmention of Drinking Water Supplies", Natural Resources Management Ministerial Council, 2008.
M.H. Plumlee, M. Löpez-Mesas, A. Heidlberger, K.P. Ishida, M. Reinhard, Water Res., 2008, 42, 347.
J.W. Munch and M.V. Bassett, "Determination of Nitrosamines in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography with Large Volume Injection and Chemical Ionization Tandem Mass Spectrometry (MS/MS)", 2004, US Environmental Protection Agency, Cincinnati, OH.
Y.-H. Chuang, F. Shabani, J. Munoz, R. Aflaki, S.D. Hammond, W.A. Mitch, Chemosphere, 2019, 227, 597.
H. Kodamatani, S. Yamazaki, K. Saito, A. Amponsaa-Karikari, N. Kishikawa, N. Kuroda, T. Tomiyasu, Y. Komatsu, J. Chromatogr., A, 2009, 7276, 92.
H. Kodamatani, S.L. Roback, M.H. Plumlee, K.P. Ishida, H. Masunaga, N. Maruyama, T. Fujioka, J. Chromatogr., A, 2018, 7553, 51.
S.L. Roback, H. Kodamatani, T. Fujioka, M.H. Plumlee, Environ. Sci. Water Res. Technol., 2020, 6, 1106.
H. Kodamatani, H. Yamasaki, T. Sakaguchi, S. Itoh, Y. Iwaya, M. Saga, K. Saito, R. Kanzaki, T. Tomiyasu, J. Chromatogr., A, 2016, 7460, 202.
M.C. Meadows, S.M. Pradhanang, T. Fujioka, H. Kodamatani, M.B. Leddy, T.B. Boving, Water, 2019, 77, https://doi.org/10.3390/w1102019.
M.M. Tin, G. Anioke, O. Nakagoe, S. Tanabe, H. Kodamatani, L.D. Nghiem, T. Fujioka, Sep. Purif. Technol., 2017, 789, 170.
T. Fujioka, H. Takeuchi, H. Tanaka, H. Kodamatani, Chemosphere, 2018, 200, 80.
T. Fujioka, H. Kodamatani, H. Aizawa, S. Gray, K.P. Ishida, L.D. Nghiem, Water Res., 2017, 778, 187.
T. Fujioka, H. Kodamatani, W. Yujue, K.D. Yu, E.R. Wanjaya, H. Yuan, M. Fang, S.A. Snyder, J. Membr. Sci., 2019, 595, 117577.
T. Fujioka, H. Yoshikawa, M. Eguchi, S. Boivin, H. Kodamatani, Chemosphere, 2020, 240, 124939.
D.P. Rounbehler and J.M. Fajen, "N-Nitroso Compounds in the Factory Environment", 1983, National Institute for Occupational Safety and Health.
M. Aragön, R.M. Marcé, F. Borrull, Talanta, 2013, 775, 896.
H. Kodamatani, S. Yamazaki, K. Saito, T. Tomiyasu, Y. Komatsu, J. Chromatogr., A, 2009, 7276, 3163.
H. Sakai, T. Takamatsu, K. Kosaka, N. Kamiko, S. Takizawa, Chemosphere, 2012, 89, 702.
F. Breider and U. von Gunten, Anal. Chem., 2017, 89, 1574.
I. Velo-Gala, M.J. Farré, J. Radjenovic, W. Gernjak, Environ. Sci. Technol. Lett., 2019, acs.estlett.8b00667.
M.H. Plumlee and M. Reinhard, Environ. Sci. Technol., 2007, 41, 6170.
Y. Qiu, E. Bei, S. Xie, S. Li, J. Wang, X. Zhang, S. Krasner, C. Chen, Sci. Total Environ., 2019, 697, 133993.
S. Masada, G. Tsuji, R. Arai, N. Uchiyama, Y. Demizu, T. Tsutsumi, Y. Abe, H. Akiyama, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda, Sci. Rep., 2019, 9, 11852.
D.S. Lim, T.H. Roh, M.K. Kim, Y.C. Kwon, S.M. Choi, S.J. Kwack, K.B. Kim, S. Yoon, H.S. Kim, B.-M. Lee, J. Toxicol. Environ. Health, Part A, 2018, 81, 465.
F. Bacaro, E. Dickenson, R.A. Trenholm, D. Gerrity, Environ. Sci. Water Res. Technol., 2019, 5, 713.
S. Spahr, O.A. Cirpka, U. von Gunten, T.B. Hofstetter, Environ. Sci. Technol., 2017, 51, 280.
Y.J. Wang, F. Dang, J.T. Zhao, H. Zhong, Environ. Pollut., 2016, 213, 232.
M.E. Huang, S. Huang, D.L. McCurry, Environ. Sci. Technol. Lett., 2018, 5, 154.
A.M. Dietrich, D.L. Gallagher, P.M. DeRosa, D.S. Millington, F.A. DiGiano, Environ. Sci. Technol., 1986, 20, 1050.
H. Kodamatani, Y. Iwaya, M. Saga, K. Saito, T. Fujioka, S. Yamazaki, R. Kanzaki, T. Tomiyasu, Anal. Chim. Acta, 2017, 952, 50.
L.P. Padhye, B. Hertzberg, G. Yushin, C.H. Huang, Environ. Sci. Technol., 2011, 45, 8368.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Kodamatani, H., Sugihara, K., Tanisue, T. et al. Contamination, Decomposition, and Formation of N-Nitrosodimethylamine in Water Samples at the ng/L Level of Determination. ANAL. SCI. 36, 1393–1397 (2020). https://doi.org/10.2116/analsci.20P162
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.2116/analsci.20P162