Abstract
A highly sensitive and selective fluorometric method for the determination of histamine and histidine has been developed. This method is based on an intramolecular excimer-forming fluorescence derivatization with a pyrene reagent followed by reversed-phase liquid chromatography. The analytes, containing two amino moieties in a molecule, were converted to the corresponding dipyrene-labeled derivatives by derivatization. The derivatives afforded intramolecular excimer fluorescence (440-540 nm), which can clearly be discriminated from the normal fluorescence (360-420 nm) emitted from reagent blanks. The detection limits (signal-to-noise ratio = 3) were femto mole levels.
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Yoshida, H., Ichinose, F., Yoshitake, T. et al. Simultaneous Determination of Histamine and Histidine by Liquid Chromatography Following Intramolecular Excimer-forming Fluorescence Derivatization with Pyrene-labeling Reagent. ANAL. SCI. 20, 557–559 (2004). https://doi.org/10.2116/analsci.20.557
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DOI: https://doi.org/10.2116/analsci.20.557