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Sensitive Determination of Domoic Acid Using High-Performance Liquid Chromatography with Electrogenerated Tris(2,2′-bipyridine)ruthenium(III) Chemiluminescence Detection

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Abstract

A new sensitive determination method of domoic acid based on the chemiluminescent reaction of tris(2,2′-bipyridine)ruthenium(III) has been developed. The method exhibited good reproducibility. The relative standard deviation of six replicate measurements was 1.6% for 10 ng ml−1. A calibration graph, based on a standard domoic acid solution, was linear over the range of 1–500 ng ml−1 (coefficient of correlation, r2 = 0.9995) and the detection limit was 8 pg (signal-to-noise ratio = 3) without any preconcentration and derivatization steps. This new method was successfully applied to a real sample of blue mussels spiked with 2 µg g−1 domoic acid.

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Authors and Affiliations

  1. Graduate School of Cultural Studies and Human Science, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, 657-8501, Japan

    Hitoshi Kodamatani

  2. Division of Natural Environment and Chemistry, Faculty of Human Development, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, 657-8501, Japan

    Keiitsu Saito & Akihiko Muromatsu

  3. Department of Applied Science, Okayama University of Science, 1-1 Ridaicho, Okayama, 700-0005, Japan

    Nobumitsu Niina & Shigeo Yamazaki

  4. Comet Co., 5-33-1 Kamiaso, Aso, Kawasaki, 215-0021, Japan

    Ikuo Sakurada

Authors
  1. Hitoshi Kodamatani
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  2. Keiitsu Saito
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  3. Nobumitsu Niina
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  4. Shigeo Yamazaki
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  5. Akihiko Muromatsu
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  6. Ikuo Sakurada
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Correspondence to Keiitsu Saito.

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Kodamatani, H., Saito, K., Niina, N. et al. Sensitive Determination of Domoic Acid Using High-Performance Liquid Chromatography with Electrogenerated Tris(2,2′-bipyridine)ruthenium(III) Chemiluminescence Detection. ANAL. SCI. 20, 1065–1068 (2004). https://doi.org/10.2116/analsci.20.1065

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  • DOI: https://doi.org/10.2116/analsci.20.1065

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