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Development of Directly Coupled Supercritical Fluid Chromatography-Mass Spectrometry with Self-Spouting and Vacuum Nebulizing Assisted Interface

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Abstract

Supercritical fluid chromatograph (SFC) with a fused silica separation column (0.5 mm I.D.×70 cm) packed with ODS-Q3 (30-50 μm) was directly coupled with a quadrupole mass spectrometer (MS) through a vacuum nebulizing interface originally developed for the combination of high performance liquid chromathograph (HPIC) with MS. Mixtures of hexane and ethanol were used as the mobile phase for SFC at a flow rate of 40 μl/min (50 kg/cm2). The column temperatures were maintained above the critical ones of the mobile phase between 260 and 280°C. Introduction of line filters to remove possible small particles in the SFC effluent and the subtle control of the optimum flow and/or the pressure for the SFC column enabled fairly long term stable operation for this SFC-MS system. Thus developed new system was successfully applied to the analysis of various samples such as styrene oligomers, phthalates, triglycerides, and polyethylene glycol derivatives.

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Authors and Affiliations

  1. Department of Synthetic Chemistry, Faculty of Engineering, Nagoya University, Nagoya, 464, Japan

    Kozo Matsumoto & Shin Tsuge

  2. School of Materials Science, Toyohashi University of Technology, Toyohashi, 440, Japan

    Yukio Hirata

Authors
  1. Kozo Matsumoto
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  2. Shin Tsuge
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  3. Yukio Hirata
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Matsumoto, K., Tsuge, S. & Hirata, Y. Development of Directly Coupled Supercritical Fluid Chromatography-Mass Spectrometry with Self-Spouting and Vacuum Nebulizing Assisted Interface. ANAL. SCI. 2, 3–7 (1986). https://doi.org/10.2116/analsci.2.3

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  • DOI: https://doi.org/10.2116/analsci.2.3

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