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Taste Sensor: Electronic Tongue with Lipid Membranes

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Abstract

Taste is of five basic types, namely, sourness, saltiness, sweetness, bitterness and umami. In this review, we focus on a potentiometric taste sensor that we developed and fabricated using lipid polymer membranes. The taste sensor can measure the taste perceived by humans and is called an electronic tongue with global selectivity, which is the property to discriminate taste qualities and quantify them without discriminating each chemical substance. This property is similar to the gustatory system; hence, the taste sensor is a type of biomimetic device. In this paper, we first explain the sensing mechanism of the taste sensor, its application to beer evaluation and the measurement mechanism. Second, results recently obtained are introduced; i.e., the application of the senor to high-potency sweeteners and the improvement of the bitterness sensor are explained. Last, quantification of the bitterness-masking effect of high-potency sweeteners is explained using a regression analysis based on both the outputs of bitterness and sweetness sensors. The taste sensor provides a biomimetic method different from conventional analytical methods.

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References

  1. K. Ikeda, Chem. Senses, 2002, 27, 847.

    Article  PubMed  Google Scholar 

  2. G. Nelson, J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao, N. J. P. Ryba, and C. S. Zuker, Nature, 2002, 416, 199.

    Article  CAS  PubMed  Google Scholar 

  3. D. Gaillard and S. C. Kinnamon, Acta Physiol., 2019, 226, e13246.

    Article  Google Scholar 

  4. J. Chandrashekar, K. L. Mueller, M. A. Hoon, E. Adler, L. Feng, W. Guo, C. S. Zuker, and N. J. P. Ryba, Cell, 2000, 100, 703.

    Article  CAS  PubMed  Google Scholar 

  5. G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. P. Ryba, and C. S. Zuker, Cell, 2001, 106, 381.

    Article  CAS  PubMed  Google Scholar 

  6. C. Montell, Science, 2018, 359, 991.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. A. L. Huang, X. Chen, M. A. Hoon, J. Chandrashekar, W. Guo, D. Trankner, N. J. P. Ryba, and C. S. Zuker, Nature, 2006, 442, 934.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. J. Chandrashekar, C. Kuhn, Y. Oka, D. A. Yarmolinsky, E. Hummler, N. J. P. Ryba, and C. S. Zuker, Nature, 2010, 464, 297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. L. J. Falomir-Lockhart, G. F. Cavazzutti, E. Giménez, and A. M. Toscani, Front. Cell. Neurosci., 2019, 13, 1

    Article  Google Scholar 

  10. K. Yasumatsu, S. Iwata, M. Inoue, and Y. Ninomiya, Acta Physiol., 2019, 226, e13215.

    Article  Google Scholar 

  11. S.-J. Lee, I. Depoortere, and H. Hatt, Nat. Rev. Drug Discov., 2019, 18, 116.

    Article  CAS  PubMed  Google Scholar 

  12. Y. Vlasov, A. Legin, A. Rudnitskaya, C. Di Natale, and A. D’Amico, Pure Appl. Chem., 2005, 77, 1965.

    Article  CAS  Google Scholar 

  13. C. Di Natale, A. D'amico, Y. G. Vlasov, A. V. Legin, and A. M. Rudnitskaya, Proc. Intern. Conf. EUROSENSORS IX, 1995, 36.

  14. F. Winquist, P. Wide, and I. Lundström, Anal. Chim. Acta, 1997, 357, 21.

    Article  CAS  Google Scholar 

  15. F. Winquist, Microchim. Acta, 2008, 163, 3.

    Article  CAS  Google Scholar 

  16. F. Winquist, I. Lundström, and P. Wide, Sens. Actuators, B, 1999, 58, 512.

    Article  CAS  Google Scholar 

  17. Y. G. Vlasov, E. A. Bychkov, and A. V. Legin, Talanta, 1994, 41, 1059.

    Article  CAS  PubMed  Google Scholar 

  18. A. Legin, A. Rudnitskaya, Y. Vlasov, C. Di Natale, F. Davide, and A. D'Amico, Sens. Actuators, B, 1997, 44, 291.

    Article  CAS  Google Scholar 

  19. J. Wang, L. Zhu, W. Zhang, and Z. Wei, Anal. Chim. Acta, 2019, 1050, 60.

    Article  CAS  PubMed  Google Scholar 

  20. C. Garcia-Hernandez, C. Salvo Comino, F. Martín-Pedrosa, M. L. Rodriguez-Mendez, and C. Garcia-Cabezon, Sens. Actuators, B, 2018, 277, 365.

    Article  CAS  Google Scholar 

  21. C. J. Musto, S. H. Lim, and K. S. Suslick, Anal. Chem., 2009, 81, 6526.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. C. Zhang and K. S. Suslick, J. Am. Chem. Soc., 2005, 127, 11548.

    Article  CAS  PubMed  Google Scholar 

  23. G. Sehra, M. Cole, and J. W. Gardner, Sens. Actuators, B, 2004, 103, 233.

    Article  CAS  Google Scholar 

  24. C. M. Daikuzono, C. A. R. Dantas, D. Volpati, C. J. L. Constantino, M. H. O. Piazzetta, A. L. Gobbi, D. M. Taylor, O. N. Oliveira, and A. Riul, Sens. Actuators, B, 2015, 207, 1129.

    Article  CAS  Google Scholar 

  25. C. M. Daikuzono, C. Delaney, A. Morrin, D. Diamond, L. Florea, and O. N. Oliveira, Analyst, 2019, 144, 2827.

    Article  CAS  PubMed  Google Scholar 

  26. B. Zribi, D. Dragoe, and E. Scorsone, Sens. Actuators, B, 2019, 290, 147.

    Article  CAS  Google Scholar 

  27. J. S. Lee, A.-N. Cho, Y. Jin, J. Kim, S. Kim, and S.-W. Cho, Biomaterials, 2018, 151, 24.

    Article  CAS  PubMed  Google Scholar 

  28. H. S. Song, H. J. Jin, S. R. Ahn, D. Kim, S. H. Lee, U.-K. Kim, C. T. Simons, S. Hong, and T. H. Park, ACS Nano, 2014, 8, 9781.

    Article  CAS  PubMed  Google Scholar 

  29. P. Chen, X. Liu, B. Wang, G. Cheng, and P. Wang, Sens. Actuators, B, 2009, 139, 576.

    Article  CAS  Google Scholar 

  30. Q. Liu, F. Zhang, D. Zhang, N. Hu, H. Wang, K. Jimmy Hsia, and P. Wang, Biosens. Bioelectron., 2013, 40, 115.

    Article  CAS  PubMed  Google Scholar 

  31. S. R. Ahn, J. H. An, I. H. Jang, W. Na, H. Yang, K. H. Cho, S. H. Lee, H. S. Song, J. Jang, and T. H. Park, Biosens. Bioelectron., 2018, 117, 628.

    Article  CAS  PubMed  Google Scholar 

  32. K. Hayashi, M. Yamanaka, K. Toko, and K. Yamafuji, Sens. Actuators, B, 1990, 2, 205.

    Article  CAS  Google Scholar 

  33. K. Toko, Mater. Sci. Eng. C, 1996, 4, 69.

    Article  Google Scholar 

  34. Y. Tahara and K. Toko, IEEE Sens. J., 2013, 13, 3001.

    Article  Google Scholar 

  35. K. Toko, T. Onodera, and Y. Tahara, “Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences”, ed. D. Bagchi, M. Bagchi, H. Moriyama, and F. Shahidi, 2013, Blackwell Publishing Ltd., 270.

  36. K. Toko, Y. Tahara, M. Habara, Y. Kobayashi, and H. Ikezaki, “Essentials of Machine Olfaction and Taste”, ed. T. Nakamoto, 2016, Chap. 4, Wiley, 87.

  37. V. Anand, M. Kataria, V. Kukkar, V. Saharan, and P. K. Choudhury, Drug Discov. Today, 2007, 12, 257.

    Article  CAS  PubMed  Google Scholar 

  38. A. Riul Jr., C. A. R. Dantas, C. M. Miyazaki, and O. N. Oliveira Jr, Analyst, 2010, 135, 2481.

    Article  CAS  PubMed  Google Scholar 

  39. T. Haraguchi, T. Uchida, M. Yoshida, H. Kojima, M. Habara, and H. Ikezaki, Chem. Pharm. Bull., 2018, 66, 71.

    Article  CAS  Google Scholar 

  40. L. G. Dias, A. Fernandes, A. C. A. Veloso, A. A. S. C. Machado, J. A. Pereira, and A. M. Peres, Food Chem., 2014, 160, 321.

    Article  CAS  PubMed  Google Scholar 

  41. Í. Marx, N. Rodrigues, L. G. Dias, A. C. A. Veloso, J. A. Pereira, D. A. Drunkler, and A. M. Peres, Talanta, 2017, 162, 98.

    Article  CAS  PubMed  Google Scholar 

  42. Í. M. G. Marx, N. Rodrigues, L. G. Dias, A. C. A. Veloso, J. A. Pereira, D. A. Drunkler, and A. M. Peres, LWT—Food Sci. Technol., 2017, 79, 394.

    Article  CAS  Google Scholar 

  43. G. Sharma, S. Kumar, A. Kumar, A. Sharma, R. Kumar, R. Kaur, and A. P. Bhondekar, Procedia Comput. Sci., 2015, 70, 146.

    Article  Google Scholar 

  44. P. Ciosek and W. Wróblewski, Analyst, 2007, 132, 963.

    Article  CAS  PubMed  Google Scholar 

  45. T. U. Tran, K. Suzuki, H. Okadome, S. Homma, and K. Ohtsubo, Food Chem., 2004, 88, 557.

    Article  CAS  Google Scholar 

  46. N. Hayashi, T. Ujihara, R. Chen, K. Irie, and H. Ikezaki, Food Res. Int., 2013, 53, 816.

    Article  CAS  Google Scholar 

  47. A. Totsuka, “Biochemical Sensors: Mimicking Gustatory and Olfactory Senses”, ed. K. Toko, 2013, Pan Stanford Publishing.

  48. K. Toko and Y. Tahara, “Electronic Noses and Tongues in Food Science”, ed. M. L. Rodriguez Mendez, 2016, Chap. 16, Academic Press, Oxford, 161.

  49. K. Sasaki, F. Tani, K. Sato, H. Ikezaki, A. Taniguchi, T. Emori, F. Iwaki, K. Chikuni, and M. Mitsumoto, Sensors Mater., 2005, 17, 397.

    CAS  Google Scholar 

  50. Y. H. Hwang, I. Ismail, and S. T. Joo, Korean J. Food Sci. Anim. Resour., 2018, 38, 1305.

    Article  PubMed  PubMed Central  Google Scholar 

  51. T. Ishiwaki, “Biochemical Sensors: Mimicking Gustatory and Olfactory Senses”, ed. K. Toko, 2013, Pan Stanford Publishing, 83.

  52. X. Zhang, Y. Zhang, Q. Meng, N. Li, and L. Ren, PLoS One, 2015, 10, e0137807.

    Article  PubMed  PubMed Central  Google Scholar 

  53. N. Anjiki, J. Hosoe, H. Fuchino, F. Kiuchi, S. Sekita, H. Ikezaki, M. Mikage, N. Kawahara, and Y. Goda, J. Nat. Med., 2011, 65, 293.

    Article  PubMed  Google Scholar 

  54. M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz, and W. Weitschies, Int. J. Pharm., 2012, 438, 81.

    Article  CAS  PubMed  Google Scholar 

  55. Y. Kobayashi, H. Hamada, Y. Yamaguchi, H. Ikezaki, and K. Toko, IEEJ Trans. Electr. Electron. Eng., 2009, 4, 710.

    Article  CAS  Google Scholar 

  56. T. Harada, T. Uchida, M. Yoshida, Y. Kobayashi, R. Narazaki, and T. Ohwaki, Chem. Pharm. Bull., 2010, 58, 1009.

    Article  CAS  Google Scholar 

  57. M. Okamoto, H. Sunada, M. Nakano, and R. Nishiyama, Asian J. Pharm. Sci., 2009, 4, 1.

    Google Scholar 

  58. M. Pein, M. Preis, C. Eckert, and F. E. Kiene, Int. J. Pharm., 2014, 465, 239.

    Article  CAS  PubMed  Google Scholar 

  59. M. Preis, L. Grother, P. Axe, and J. Breitkreutz, Int. J. Pharm., 2015, 497, 8.

    Article  Google Scholar 

  60. T. Uchida, M. Yoshida, M. Hazekawa, T. Haraguchi, H. Furuno, M. Teraoka, and H. Ikezaki, J. Pharm. Pharmacol., 2013, 65, 1312.

    Article  CAS  PubMed  Google Scholar 

  61. Y. Bi, H. Sunada, Y. Yonezawa, K. Danjo, A. Otsuka, and K. Iida, Chem. Pharm. Bull., 1996, 44, 2121.

    Article  CAS  Google Scholar 

  62. R. Kakutani, H. Muro, and T. Makino, Chem. Pharm. Bull., 2010, 58, 885.

    Article  Google Scholar 

  63. K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz, J. Pharm. Biomed. Anal., 2011, 55, 272.

    Article  CAS  PubMed  Google Scholar 

  64. G. A. Campbell, J. A. Charles, K. Roberts-Skilton, M. Tsundupalli, C. K. Oh, A. Weinecke, R. Wagner, and D. Franz, Powder Technol., 2012, 224, 109.

    Article  CAS  Google Scholar 

  65. X. Tian, J. Wang, R. Shen, Z. Ma, and M. Li, Int. J. Food Sci. Technol., 2019, 54, 670.

    Article  CAS  Google Scholar 

  66. J. Do Kim, H. G. Byun, D. J. Kim, Y. K. Ham, W. S. Jung, and C. O. Yoon, Talanta, 2006, 70, 546.

    Article  Google Scholar 

  67. K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz, Int. J. Pharm., 2011, 477, 256.

    Article  Google Scholar 

  68. Y. Kobayashi, M. Habara, H. Ikezazki, R. Chen, Y. Naito, and K. Toko, Sensors, 2010, 70, 3411.

    Article  Google Scholar 

  69. A. Inc., No Title, https://aissy.co.jp/.

  70. M. del Valle, Int. J. Electrochem., 2012, 2072, 11.

    Google Scholar 

  71. K. Toko, “Biomimetic Sensor Technology”, 2000, Cambridge University Press.

    Book  Google Scholar 

  72. Y. G. Vlasov, A. V. Legin, and A. M. Rudnitskaya, Russ. J. Gen. Chem., 2008, 78, 2532.

    Article  CAS  Google Scholar 

  73. L. Escuder-Gilabert and M. Peris, Anal. Chim. Acta, 2010, 665, 15.

    Article  CAS  PubMed  Google Scholar 

  74. T. Haraguchi, M. Yoshida, H. Kojima, and T. Uchida, Asian J. Pharm. Sci., 2016, 77, 479.

    Article  Google Scholar 

  75. H. Ikezaki, A. Taniguchi, and K. Toko, IEEJ Trans. Sensors Micromachines, 1997, 777, 465.

    Article  Google Scholar 

  76. M. Habara and K. Toko, “Encyclopedia of Sensors”, 2006, Vol. 10, American Scientific Publishers, 107.

    CAS  Google Scholar 

  77. M. Habara and K. Toko, “Bottom-Up Nanofabrication”, ed. K. Ariga and S. N. Hari, 2009, Vol. 6, American Scientific Publishers, 91.

    Google Scholar 

  78. I. Insent, Rep. Risk-taking Fund Technol. Dev., 2007, 25.

    Google Scholar 

  79. R. Yatabe, J. Noda, Y. Tahara, Y. Naito, H. Ikezaki, and K. Toko, Sensors, 2015, 75, 22439.

    Article  Google Scholar 

  80. C. Belloir, F. Neiers, and L. Briand, Curr Opin Clin Nutr Metab Care, 2017, 20, 279.

    Article  CAS  PubMed  Google Scholar 

  81. K. Toyota, H. Cui, K. Abe, M. Habara, K. Toko, and H. Ikezaki, Sensors Mater., 2011, 23, 465.

    CAS  Google Scholar 

  82. K. Toyota, H. Cui, K. Abe, M. Habara, K. Toko, and H. Ikezaki, Sensors Mater., 2011, 23, 475.

    CAS  Google Scholar 

  83. M. Yasuura, Q. Shen, Y. Tahara, R. Yatabe, and K. Toko, Sensors Mater., 2015, 27, 351.

    Google Scholar 

  84. N. A. Miele, E. K. Cabisidan, A. Galinanes Plaza, P. Masi, S. Cavella, and R. Di Monaco, Trends Food Sci. Technol., 2017, 64, 87.

    Article  CAS  Google Scholar 

  85. R. Di Monaco, N. A. Miele, E. K. Cabisidan, and S. Cavella, Curr. Opin. Food Sci., 2018, 79, 92.

    Article  Google Scholar 

  86. A. D. Mooradian, M. Smith, and M. Tokuda, Clin Nutr ESPEN, 2017, 78, 1.

    Article  Google Scholar 

  87. B. Sik, FoodAnal. Methods, 2012, 5, 1443.

    Google Scholar 

  88. M. Yasuura, H. Okazaki, Y. Tahara, H. Ikezaki, and K. Toko, Sens. Actuators, B, 2014, 207, 329.

    Article  Google Scholar 

  89. M. Yasuura, Y. Tahara, H. Ikezaki, and K. Toko, Sensors, 2014, 74, 7359.

    Article  Google Scholar 

  90. Y. Tahara, T. Hattori, X. Wu, R. Yatabe, H. Ikezaki, M. Habara, and K. Toko, in 2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 2017, Montreal, 265–266.

  91. H. Okazaki, M. Yasuura, Y. Tahara, H. Ikezaki, and K. Toko, Japanese J. Tast. Smell Res., 2014, 27, 395.

    Google Scholar 

  92. S. K. Goyal, Samsher, and R. K. Goyal, Int. J. Food Sci. Nutr., 2010, 67, 1.

    Article  Google Scholar 

  93. V. Chatsudthipong and C. Muanprasat, Pharmacol. Ther., 2009, 727, 41.

    Article  Google Scholar 

  94. T. Harada, T. Uchida, M. Yoshida, Y. Kobayashi, R. Narazaki, and T. Ohwaki, Chem. Pharm. Bull., 2010, 58, 1009.

    Article  CAS  Google Scholar 

  95. T. Haraguchi, T. Uchida, M. Yoshida, H. Kojima, M. Habara, and H. Ikezaki, Chem. Pharm. Bull., 2018, 66, 71.

    Article  CAS  Google Scholar 

  96. X. Wu, H. Onitake, Z. Huang, T. Shiino, Y. Tahara, R. Yatabe, H. Ikezaki, and K. Toko, Sensors, 2017, 77, 2541.

    Article  Google Scholar 

  97. K. Toko, D. Hara, Y. Tahara, M. Yasuura, and H. Ikezaki, Sensors, 2014, 74, 16274.

    Article  Google Scholar 

  98. T. Sugiura, S. Uchida, and N. Namiki, Chem. Pharm. Bull., 2012, 60, 315.

    Article  CAS  Google Scholar 

  99. V. Sharma and H. Chopra, Int. J. Pharm. Pharm. Sci., 2010, 2, 14.

    CAS  Google Scholar 

  100. S. S. Schiffman, S. Consulting, and H. Place, Chem Senses., 2012, 37, 671.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Y. Harada, Y. Tahara, and K. Toko, Sensors, 2015, 15, 6241.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Y. Katsuragi, T. Yasumasu, and K. Kurihara, Brain Res., 1996, 713, 240.

    Article  CAS  PubMed  Google Scholar 

  103. Y. Katsuragi and K. Kurihara, Nature, 1993, 365, 213.

    Article  CAS  PubMed  Google Scholar 

  104. T. Fukagawa, Y. Tahara, M. Yasuura, M. Habara, H. Ikezaki, and K. Toko, J. Innov. Electron. Commun., 2012, 2, 1.

    Google Scholar 

  105. X. Wu, H. Onitake, T. Haraguchi, Y. Tahara, R. Yatabe, M. Yoshida, T. Uchida, H. Ikezaki, and K. Toko, Sens. Actuators, B, 2016, 235, 11.

    Article  CAS  Google Scholar 

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Wu, X., Tahara, Y., Yatabe, R. et al. Taste Sensor: Electronic Tongue with Lipid Membranes. ANAL. SCI. 36, 147–159 (2020). https://doi.org/10.2116/analsci.19R008

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