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Novel Ibuprofen Potentiometric Membrane Sensors Based on Tetraphenylporphyrinato Indium(III)

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Abstract

Two novel potentiometric membrane sensors responsive to the ibuprofen drug have been developed. These incorporate poly(vinyl chloride) and polyurethane matrix membranes containing 5,10,15,20-tetraphenylporphrinato (TPP) indium(III) ionophore plasticized with dibutylsebacate. The sensors show a near-Nernstian response with anionic slopes of-53 and-55 mV decade−1, over the concentration range of 4.2 × 10−6-1.0 × 10−2 and 3.3 × 10−6-1.0 × 10−2 M ibuprofen within pH ranges of 4–9 and 5–9 for PVC and PU matrix membranes, respectively. A sensor based on a polyurethane membrane displays a lower detection limit and a wider linear working range, and a sensor based on a PVC membrane exhibits a better overall selectivity, especially in the presence of lipophilic organic anions. Both sensors are used for the quantification and quality-control assessment of ibuprofen in pharmaceutical preparations. The average recoveries are 99.1±0.3% and 99.3±0.3% for TPP In(III)-PVC and TPP In(III)-PU based membrane sensors, respectively. High selectivities towards ibuprofen in the presence of many anions, drug excipients and diluents are offered by both sensors, which exhibit a non-Hofmeister selectivity pattern.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

    Saad S. M. Hassan, Wagiha H. Mahmoud & Mahra H. Almarzooqi

  2. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

    Mohamed A. F. Elmosallamy

Authors
  1. Saad S. M. Hassan
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  2. Wagiha H. Mahmoud
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  3. Mohamed A. F. Elmosallamy
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  4. Mahra H. Almarzooqi
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Correspondence to Saad S. M. Hassan.

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Hassan, S.S.M., Mahmoud, W.H., Elmosallamy, M.A.F. et al. Novel Ibuprofen Potentiometric Membrane Sensors Based on Tetraphenylporphyrinato Indium(III). ANAL. SCI. 19, 675–679 (2003). https://doi.org/10.2116/analsci.19.675

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