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A Label-free and Universal Platform for the Construction of Various Logic Circuits Based on Graphene Oxide and G-Quadruplex Structure

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Abstract

Due to structual polymorphism, excellent binding activity and functional significances in biological regulation, G-quadruplex has become the focus of research as an innovated module for analytical chemistry and biomedicine. Meanwhile, in the biosensor fields, new nanomaterial graphene oxide (GO) has also received extensive attention due to its brilliant physical and chemical properties. Herein, we propose a non-label and enzyme-free logic operation platform based on G-quadruplex structure and GO instead of any expensive modification. Taking advantage of the quenching ability of GO to AgNCs and the fluorescence enhancement of NMM (N-methylmesoporphyrin IX) mediated by the split G-quadruplex, a series of binary logic gates (AND, OR, INHIBIT, XOR) have been constructed and verified by biological experiments. Subsequently, two combinatorial logic gates were successfully realized conceptually on the basis of the same BGG platform, including half adder and half subtractor. Taken together, such a universal platform has great potential in applications, such as biocomputing, bio-imaging and disease diagnosis, which cultivate a new view for future biological research.

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Acknowledgments

This research is supported by National Natural Science Foundation of China (Grant No. 61572302, No. 61272246).

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Authors and Affiliations

  1. School of Computer Science, Shaanxi Normal University, Xi’an, 710119, China

    Yingying Zhang

  2. College of Life Sciences, Shaanxi Normal University, Xi’an, 710119, China

    Luhui Wang & Yafei Dong

  3. Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, Xi’an, 710119, China

    Yafei Dong

Authors
  1. Yingying Zhang
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  2. Luhui Wang
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  3. Yafei Dong
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Correspondence to Yafei Dong.

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Zhang, Y., Wang, L. & Dong, Y. A Label-free and Universal Platform for the Construction of Various Logic Circuits Based on Graphene Oxide and G-Quadruplex Structure. ANAL. SCI. 35, 181–187 (2019). https://doi.org/10.2116/analsci.18P349

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  • DOI: https://doi.org/10.2116/analsci.18P349

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