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Recent Progress in the Development of Microfluidic Vascular Models

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Abstract

The blood vessel is part of the circulatory system, and systemic circulation provides the blood supply to all tissues. Arteries are pathways through which the blood is carried, and the capillaries have a key role in material exchange to maintain the tissue environment. Blood vessels have structures appropriate for their functions, and their sizes and cell types are different. In this review, we introduced recent studies of the microfluidic vascular models. The model structures are classified mainly as poly(dimethylsiloxane) and hydrogel microchannels and self-assembled networks. Basic phenomena and functions were realized in vascular models, including fluid shear stress, cell strain, interstitial flow, endothelial permeation, angiogenesis, and thrombosis. In some models, endothelial cells were co-cultured with smooth muscle cells, pericytes, and fibroblasts in an extracellular matrix. Examples of vascular models involving the brain, lung, liver, kidney, placenta, and cancer were also introduced.

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Acknowledgments

This work was supported in part by the Asahi Glass Foundation and The Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP16H04170 to Kae Sato; JP15H03823 and JP15K13719 to Kiichi Sato.

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  1. Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, Bunkyo, Tokyo, 112-8681, Japan

    Kae Sato

  2. Department of Chemistry and Chemical Biology, School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan

    Kiichi Sato

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  1. Kae Sato
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Correspondence to Kiichi Sato.

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Sato, K., Sato, K. Recent Progress in the Development of Microfluidic Vascular Models. ANAL. SCI. 34, 755–764 (2018). https://doi.org/10.2116/analsci.17R006

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