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Construction and Performance Characteristics of New Fentanyl-Selective Plastic Membrane Electrode

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Abstract

The construction and performance characteristics of an ion-selective electrode for fentanyl-drug cation, based on an ion-pair complex with tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate anion in a PVC matrix were studied. A linear response for 1 × 10–5 mol dm–3 to 1 × 10–2 mol dm–3 drug with a slope of 57.9 ± 0.5 mV/decade was established. The optimum pH range was 2 to 6. The lower detection limit was 6.29 × 10–6 mol dm–3 fentanyl citrate (2.1165 µg cm–3 fentanyl). There were negligible interferences from a number of inorganic cations, structural analogues, and some common drug additives in injections. The electrode proposed has been successfully applied to determine fentanyl citrate in injections. The results correlated well with those obtained by the United States Pharmacopoeia standard procedure.

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Authors and Affiliations

  1. Department of Chemistry, Yunnan University, Kunming, Yunnan, 650091, China

    Li Juan Peng, Meng Liang Wen & Yun Yao

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  1. Li Juan Peng
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  2. Meng Liang Wen
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  3. Yun Yao
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Correspondence to Meng Liang Wen.

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Peng, L.J., Wen, M.L. & Yao, Y. Construction and Performance Characteristics of New Fentanyl-Selective Plastic Membrane Electrode. ANAL. SCI. 17, 815–818 (2001). https://doi.org/10.2116/analsci.17.815

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  • DOI: https://doi.org/10.2116/analsci.17.815

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