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Design and Application of Piezoelectric Quartz Crystal-based Immunoassay

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Abstract

This paper describes some basic test schemes of piezoelectric quartz crystal microbalance (QCM)-based immunoassay. These include one-step direct assay, one-step indirect assay, two-step sandwiched assay, displacement assay, and mass-amplified assay. Applications of these designs in the fields of clinic diagnosis, food analysis, environmental analysis, and veterinary diagnosis are reviewed. In addition, some critical issues of QCM immunoassay are also dealt with, including the evaluation of liquid phase and gas phase detection, and the biomolecules’ coating techniques, non-specific adsorption, and regeneration of used crystals.

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5 References

  1. D. Wild, “The immunoassay handbook”, 1977, Stokton Press, New York, 618.

    Google Scholar 

  2. J. E. Roederer and G. J. Bastianns, Anal. Chem., 1983, 55, 2333.

    Article  CAS  Google Scholar 

  3. J. W. Grate, S. J. Martin, and R. M. White, Anal. Chem., 1993, 65, (a) 940, (b) 987.

    Article  Google Scholar 

  4. G. Z. Sauerbrey, Phys., 1959, 155, 206.

    CAS  Google Scholar 

  5. R. Bruckenstein and M. Shay, Electrochim. Acta, 1985, 30, 1295.

    Article  CAS  Google Scholar 

  6. K. K. Kanazawa and J. G. Gordon, Anal. Chem., 1985, 57, 1771.

    Article  Google Scholar 

  7. F. T. Richard, S. S. Jerome, “Handbook of Chemical and Biochemical Sensors”, 1977, Institute of Physics Publishing, Washington, D.C., 484.

    Google Scholar 

  8. A. Shons et al., J. Biomed. Mater. Res., 1972, 6, 565.

    Article  CAS  PubMed  Google Scholar 

  9. J. Ngeh, A. A. Suleiman, and G. G. Guibault, Biosens. Bioelectron., 1990, 5, 13.

    Article  Google Scholar 

  10. A. A. Suleiman and G. G. Guibault, Analyst, 1994, 119, 2279.

    Article  CAS  PubMed  Google Scholar 

  11. M. Minuuni, M. Mascini, and G. G. Guilbault, Anal. Lett., 1995, 28, 749.

    Article  Google Scholar 

  12. R. L Bunde, E. J. Jarvi, and J. J. Rosentreter, Talanta, 1998, 46, 1223.

    Article  CAS  PubMed  Google Scholar 

  13. C. Barnes and C. D’Silva, Sensors Actuators, 1992, B7, 347.

    Article  Google Scholar 

  14. M. Minunni, P. Skladal, and M. Mascini, Anal. Lett., 1994, 27, 1475.

    Article  CAS  Google Scholar 

  15. B. Konig and M. Gratze, Anal. Lett., 1993, 26, 1567.

    Article  Google Scholar 

  16. B. Konig and M. Gratze, Anal. Lett., 1993, 26, 2313.

    Article  Google Scholar 

  17. B. Konig and M. Gratze, Anal. Chim. Acta, 1993, 281, 13.

    Article  Google Scholar 

  18. M. Muratsugu, F. Ohta, Y. Miya, T. Hosokawa, S. Kurosawa, N. Kamo, and H. Ikeda, Anal. Chem., 1993, 65, 2933.

    Article  CAS  PubMed  Google Scholar 

  19. B. Konig and M. Gratzel, Anal. Chem., 1994, 66, 341.

    Article  CAS  PubMed  Google Scholar 

  20. F. Aberl, H. Wolf, C. Kosslinger, S. Drost, P. Woias, and S. Koch, Sensors Actuators, 1994, 18B, 271.

    Article  Google Scholar 

  21. C. Kosslinger, S. Drost, F. Abrerl, H. Wolf, S. Koch, and P. Woias, Biosens Bioelectron., 1992, 7, 397.

    Article  CAS  PubMed  Google Scholar 

  22. B. Konig and M. Gratze, Bioorg. Med. Chem. Lett., 1994, 4, 2429.

    Article  Google Scholar 

  23. B. Konig and M. Gratzel, Anal. Chim. Acta, 1995, 309, 19.

    Article  Google Scholar 

  24. G. Sakai, T. Saiki, T. Udat, N. Miura, and N. Yamazoe, Sensors Actuators, 1995, 24B, 137.

    Google Scholar 

  25. X. Chu, Z. H. Lin, G. L. Shen, and R. Q. Yu, Analyst, 1995, 120, 2829.

    Article  CAS  PubMed  Google Scholar 

  26. X. Chu, Z. H. Lin, G. L. Shen, and R. Q. Yu, Chem. J. Chinese Univ., 1996, 17, 870.

    CAS  Google Scholar 

  27. D. Le, F. J. He, T. J. Jiang, L. H. Nie, and S. Z. Yao, J. Microbiol. Meth., 1995, 23, 229.

    Article  Google Scholar 

  28. S. H. Si, J. H. Chen, F. J. He, L. H. Nie, and S. Z. Yao, Chinese J. Chem., 1996, 14, 222.

    CAS  Google Scholar 

  29. I. Tajima, O. Asami, and E. Sugiura, Anal. Chim. Acta, 1998, 365, 147.

    Article  CAS  Google Scholar 

  30. J. R. Pei, J. M. Hu, Y. Hu, and Y. E. Zeng, Chem. J. Chinese Univ., 1998, 19, 363.

    CAS  Google Scholar 

  31. J. R. Pei, J. M. Hu, Y. Hu, and Y. Zhang, J. Chem. Technol. Biotechnol., 1998, 73, 59.

    Article  CAS  Google Scholar 

  32. J. M. Hu, J. R. Pei, Y. Hu, and Y. E. Zeng, Chinese J. Chem., 1998, 16, 219.

    CAS  Google Scholar 

  33. S. F. Y. Li, X. D. Su, F. T. Chew, and X. C. Zhou, Singapore Patent Application, 1998, 9801211–5.

    Google Scholar 

  34. X. D. Su, F. T. Chew, and S. F. Y. Li, Anal. Biochem., 1999, 273, 66.

    Article  CAS  PubMed  Google Scholar 

  35. M. Muramatsu and K. Kajiwara, Anal. Chim. Acta, 1986, 188, 257.

    Article  Google Scholar 

  36. C. L. Dilley and D. Dixonholl, Food Technol., 1990, 44(6), 132.

    CAS  Google Scholar 

  37. J. Ye, S. V. Letcher, and A. G. Rand, J. Food. Sci., 1997, 62, 1067.

    Article  CAS  Google Scholar 

  38. M. Plomer, G. G. Guilbault, and B. Hock, Enzyme Microb. Tech., 1992, 14, 230.

    Article  CAS  Google Scholar 

  39. R. M. Carter, J. J. Mekalanos, M. B. Jacobs, G. J. Lubrano, and G. G. Guilbault, J. Immunol. Methods, 1995, 187, 121.

    Article  CAS  PubMed  Google Scholar 

  40. M. Minunni, M. Mascini, R. M. Cater, M. B. Jacobs, G. J. Lubrano, and G. G. Guilbault, Anal. Chim. Acta, 1996, 325, 169.

    Article  CAS  Google Scholar 

  41. E. Prusaksochaczewski, J. H. T. Luong, and G. G. Guilbault, Enzyme Microb. Tech., 1990, 12, 173.

    Article  CAS  Google Scholar 

  42. S. H. Si, F. L. Ren, and W. Cheng, Fresenius’ J. Anal. Chem., 1997, 357, 1101.

    Article  CAS  Google Scholar 

  43. I. S. Park and N. Kim, Biosens. Bioelectron., 1998, 13, 1091.

    Article  CAS  PubMed  Google Scholar 

  44. J. S. Bovenizer, M. B. Jacobs, C. K. O’Sullivan, and G. G. Guilbault, Anal. Lett., 1998, 31, 1287.

    Article  CAS  Google Scholar 

  45. G. G. Guilbault, B. Hock and R. Schmid, Bisens. Bioelectron., 1992, 7, 411.

    Article  CAS  Google Scholar 

  46. K. Yokoyama, K. Ikebukuro, E. Tamiya, I. Karuby, N. Ichiki, and Y. Arikawa, Anal. Chim. Acta, 1995, 304, 139.

    Article  CAS  Google Scholar 

  47. K. Nakanishi, I. Karube, S. Hiroshi et al., Anal. Chim. Acta, 1996, 325, 73.

    Article  CAS  Google Scholar 

  48. K. Nakanishi, A. Masao, Y. Sako, Y. Ishida, H. Muguruma, and I. Karube, Anal. Lett., 1996, 29, 1247.

    Article  CAS  Google Scholar 

  49. J. Horacek and P. Skladal, Anal. Chim. Acta, 1997, 347, 43.

    Article  CAS  Google Scholar 

  50. C. Steegborn and P. Skladal, Biosens. Bioelectron., 1997, 12, 19.

    Article  CAS  PubMed  Google Scholar 

  51. K. Yun, E. Kobatake, T. Haruyama, M. L. Laukkanen, K. Keinanen, and M. Aizawa, Anal. Chim. Acta, 1998, 70, 260.

    Article  CAS  Google Scholar 

  52. Z. Y. Wu, G. L. Shen, and R. Q. Yu, Chem. J. Chinese Univ., 1997, 18, 1774.

    CAS  Google Scholar 

  53. E. Uttenthaler, C. Kosslinger, and S. Drost, Anal. Chim. Acta, 1998, 362, 91.

    Article  CAS  Google Scholar 

  54. E. Uttenthaler, C. Kosslinger, and S. Drost, Biosens. Bioelectron., 1998, 13, 1279.

    Article  CAS  PubMed  Google Scholar 

  55. X. D. Su, S. F. Y. Li, J. Kwang, and S. Low, Anal. Chim. Acta, (submitted)

  56. X. D. Su, S. F.Y. Li, J. Kwang, and S. Low, Biosens. Bioelectron. (submitted)

  57. B. S. Attili and A. A. Suleiman, Anal. Lett, 1995, 28, 2149.

    Article  CAS  PubMed  Google Scholar 

  58. B. S. Attili and A. A. Suleiman, Microchem. J., 1996, 54, 174.

    Article  CAS  Google Scholar 

  59. C. Barnes, Sensors Actuators A, 1991, 29, 59.

    Article  Google Scholar 

  60. J. R. Oliveira and S. F. Silver, 1977, US patent 4242096.

  61. T. K. Rice, 1977, US patent 4236893.

  62. T. K. Rice, 1977, US patent 4314821.

  63. J. C. Richards and D. T. Bach, 1977, US patent 4847193.

  64. M. D. Ward and R. C. Ebersole, 1977, US patent 5501986.

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Authors and Affiliations

  1. Institute of Material Research and Engineering, 3, Research Link, Singapore, 117602

    Xiaodi Su & Sam F. Y. Li

  2. Paediatrics Department, Medical Faculty, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260

    Fook Tim Chew

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  1. Xiaodi Su
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  2. Fook Tim Chew
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  3. Sam F. Y. Li
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Su, X., Chew, F.T. & Li, S.F.Y. Design and Application of Piezoelectric Quartz Crystal-based Immunoassay. ANAL. SCI. 16, 107–114 (2000). https://doi.org/10.2116/analsci.16.107

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  • DOI: https://doi.org/10.2116/analsci.16.107

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