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Poly(vinyl chloride) Membrane Electrodes for the Determination of the Antibiotic Tiamulin

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Abstract

New polymeric electrodes responding to tiamulin hydrogen fumarate were constructed by incorporating tiamulin tetraphenylborate and tiamulin phosphotungstate ion-pair complexes into PVC membranes, with the latter giving the best linear and Nernstian response. The electrodes exhibited a linear response over the concentration range 10−2-10−6 mol l−1. The pH did not affect the response of the electrodes within the range 2–8. Direct potentiometry was used to assay tiamulin hydrogen fumarate in pharmaceutical formulations and in the bulk form. The results were compared with those obtained with non-aqueous titration for the antibiotic in the bulk form and with HPLC for commercial formulations.

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Author notes

  1. Margareth R. C. Marques

    Present address: Rua Ester Samara, 111/53C, Sao Paulo, SP, 05545-180, Brazil

Authors and Affiliations

  1. Institute de Química, UNICAMP, Caixa Postal 6154, Campinas, SP, 13081-970, Brazil

    Margareth R. C. Marques & Graciliano Oliveira de Neto

Authors
  1. Margareth R. C. Marques
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  2. Graciliano Oliveira de Neto
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Marques, M.R.C., de Neto, G.O. Poly(vinyl chloride) Membrane Electrodes for the Determination of the Antibiotic Tiamulin. ANAL. SCI. 13, 457–461 (1997). https://doi.org/10.2116/analsci.13.457

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  • DOI: https://doi.org/10.2116/analsci.13.457

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