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A New Fluorescence Optical-Fiber Sensor for Colchicine

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Abstract

A new sensor for determining the colchicine concentration in aqueous solution is described which uses a bifurcated optical fiber and a micrometer-sized flow cell. The sensing membrane, which contains 2-(4-diphenylyl)-6-phenylbenzoxazole (PBBO), can form a nonfluorescent complex with colchicine and quench the membrane fluorescence. The usable determination range covers from 2×10−4 to 2×10−6 mol l−l colchicine. Satisfactory reproducibility, reversibility and a relatively short response time have been realized. Alkali and alkaline earth metal salts as well as various pharmaceutical species have little or no effect on the sensor response. The sensor can be used for determining the colchicine concentration in pharmaceutical tablets with results that are in satisfactory agreement with those obtained by the pharmacopoeial method.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Ying Wang, Kemin Wang, Wanhui Liu, Guoli Shen & Ruqin Yut

  2. Southwest China Normal University, Chongqing, Sichuan, China

    Ying Wang

Authors
  1. Ying Wang
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  2. Kemin Wang
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  3. Wanhui Liu
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  4. Guoli Shen
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  5. Ruqin Yut
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Wang, Y., Wang, K., Liu, W. et al. A New Fluorescence Optical-Fiber Sensor for Colchicine. ANAL. SCI. 13, 447–451 (1997). https://doi.org/10.2116/analsci.13.447

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  • DOI: https://doi.org/10.2116/analsci.13.447

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