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Association between C-reactive protein and mood disorder in a representative sample of the Canadian population: analysis of CHMS data 2013–2014

Abstract

Objectives

The inflammatory biomarker C-reactive protein (CRP) measures systemic inflammation and has been shown to be increased in patients with mood disorders such as depression. The objective of this study was to determine the association between self-reported mood disorders with CRP levels in a representative sample of the Canadian population using the Canadian Health Measures Survey (CHMS) data 2013–2014.

Methods

The CHMS is an ongoing national cross-sectional survey of Canadians about their general health. The current study used the data collected from Cycle 3 (2012/13) and was limited to adults aged 18 and older. Survey weights were assigned to adjust for non-response and non-random sample selection of the responding sample.

Results

Data were analyzed from 5782 respondents (400 (6.9%) self-reported mood disorders and 5382 (93.1%) reported no mood disorders). The CRP level was significantly higher among those with mood disorders than among those without (3.22 (0.17) vs. 2.34 (0.04) mg/L, p = 0.003). Respondents with CRP levels > 10.00 mg/L had 2.69 greater odds of reporting a mood disorder compared with those with CRP levels ≤ 1.00 mg/L (p = 0.02). Higher proportions of respondents with mood disorders were older, had lower BMI, had secondary education, had weak sense of community, had higher proportion of asthma or arthritis, were current/past smokers, had daily consumption of 3+ drinks of alcohol, and used prescription drugs, cannabis/hashish, or other drugs compared with those without mood disorders (all p’s < 0.05).

Conclusion

This study supported the association of CRP and mood disorder, specifically in a representative sample of the Canadian population. Targeting inflammation in depression and mood disorder warrants further study.

Résumé

Objectifs

Il a été démontré que la protéine C-réactive (PCR), un marqueur biologique qui permet de mesurer l’inflammation systémique, est élevée chez les patients hospitalisés pour des troubles de l’humeur comme la dépression. Nous avons cherché à déterminer l’association entre les troubles de l’humeur autodéclarés et les niveaux de PCR dans un échantillon représentatif de la population canadienne à l’aide des données de l’Enquête canadienne sur les mesures de la santé (ECMS) de 2013-2014.

Méthode

L’ECMS est une enquête transversale nationale continue menée auprès des Canadiennes et des Canadiens au sujet de leur état de santé général. Nous avons utilisé les données du cycle 3 de l’ECMS (2012-2013) en nous limitant aux adultes (18 ans et plus). Les poids d’enquête étaient ajustés en fonction des non-réponses et de la sélection non aléatoire de l’échantillon de répondants.

Résultats

Nous avons analysé les données de 5 782 répondants (400 [6,9%] ayant déclaré des troubles de l’humeur et 5 382 [93,1%] n’ayant déclaré aucun trouble de l’humeur). Le niveau de PCR était sensiblement plus élevé chez les répondants ayant des troubles de l’humeur que chez ceux n’ayant pas de trouble de l’humeur, soit 3,22 (0,17) c. 2,34 (0,04) mg/L, p = 0,003. Les répondants ayant des niveaux de PCR > 10,00 mg/L présentaient une probabilité 2,69 fois plus grande de déclarer un trouble de l’humeur que ceux dont les niveaux de PCR étaient ≤ 1,00 mg/L (p = 0,02). Des proportions plus élevées de répondants ayant des troubles de l’humeur étaient plus âgés et avaient un indice de masse corporelle inférieur, un diplôme d’études secondaires, un faible sentiment d’appartenance à la communauté, une proportion plus élevée d’asthme ou d’arthrite, étaient des fumeurs actuels ou passés, consommaient 3 verres d’alcool ou plus par jour et prenaient des médicaments sur ordonnance ou consommaient du cannabis/haschisch ou d’autres drogues comparativement aux répondants sans trouble de l’humeur (tous p < 0,05).

Conclusion

L’étude confirme l’association de la PCR et des troubles de l’humeur spécifiquement dans un échantillon représentatif de la population canadienne. Il serait justifié de pousser la recherche en ciblant l’inflammation dans la dépression et les troubles de l’humeur.

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Correspondence to Brenda M. Y. Leung.

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The Canadian Health Measures Survey (CHMS) has been approved by the Health Canada Research Ethics Board.

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Leung, B.M.Y., Nwoke, C. Association between C-reactive protein and mood disorder in a representative sample of the Canadian population: analysis of CHMS data 2013–2014. Can J Public Health 111, 743–751 (2020). https://doi.org/10.17269/s41997-020-00297-3

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Keywords

  • Mood disorder
  • Depression
  • CRP
  • Biomarker
  • Inflammation

Mots-clés

  • Troubles de l’humeur
  • Dépression
  • Protéine C-réactive
  • Biomarqueur
  • Inflammation