Abstract
The aim of this study was to determine the prevalence and clinical and socio-demographic characteristics of active epilepsy in the population, aged 15 and over, in the province of Trabzon in northern Turkey. We surveyed households and identified 34 epileptic patients (prevalence of 6/1,000), 28 of whom had active epilepsy (prevalence of 5/1,000). Only one case of hot water epilepsy was established among the 5,254 participants. Of the various seizure types, the most common were partial seizures (63%), over half of which were secondary generalised seizures. The largest syndromic category was that of localisation-related symptomatic cases (46%). Forty-six percent of cases were of unknown cause, and 16% were resistant to medication. The prevalence rate of active epilepsy in Trabzon is low compared to other parts of Turkey and other developing countries. This may be attributable to several factors, and particularly to variations among socio-economic factors. The population of Trabzon is regarded as relatively stable and homogenous, and socio-demographic and health data for the province of Trabzon are much better than those for the rest of the country.
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Annegers JF, Grabow JD, Groover RV. Laws ER Jr, Elveback LR, Kurland LT. Seizures after head trauma: a population study. Neurology 1980;30:683–689.
Antiepileptic Drug Withdrawal Study Group, Medical Research Council. Lancet 1991; 337: 1175–1180.
Aziz H, Ali SM, Frances P, Khan MI, Hasan KZ. Epilepsy in Pakistan: a population-based epidemiologic study. Epilepsia 1994;35:950–958.
Aziz H, Güvener A, Akhtar SW, Hasan KZ. Comparative epidemiology of epilepsy in Pakistan and Turkey: population-based studies using identical protocols. Epilepsia 1997;38:716–722.
Banerjee PN, Hauser WA. Incidence and Prevalence. In: Engel J, Pedley TA, eds. Epilepsy A Comprehensive Textbook. Philadelphia: Lippincott Williams & Wilkins, 2008:45–56.
Bebek N, Gurses C, Gokyigit A, Baykan B, Ozkara C, Dervent A. Hot water epilepsy: clinical and electrophysiological findings based on 21 cases. Epilepsia 2001;42:1180–1184.
Beghi E and Sander JW. The natural history and prognosis of epilepsy. In: Engel J, Pedley TA. Epilepsy A Comprehensive Textbook, second edition. Philadelphia: Lippincott Williams & Wilkins, 2008:65–70.
Bilgin Y. Toplumda Epilepsi Sorunu. Ankara Üniversitesi Tıp Fakültesi Mecmuas? 1980;33:445–458.
Birbeck GL, Kalichi EMN. Epilepsy prevalence in rural Zambia: a door-to-door survey. Tropical Medicine and International Health 2004;9:92–95.
Boon PA, De Deyn PP, Hauman E, et al. Epidemiology of epilepsy in Flanders (Belgium). Epilepsia 1995; 36(Suppl. 3): 17.
Burneo JG, Tellez-Zenteno J, Wiebe S. Understanding the burden of epilepsy in Latin America: A systematic review of its prevalence and incidence. Epilepsy Research 2005;66:63–74.
Çalişir N, Bora I, Irgin E, Boz M. Prevalence of epilepsy in Bursa City Center, an urban area of Turkey. Epilepsia 2006;47:1691–1699.
Centers for Disease Control. Current trends: prevalence of selfreported epilepsy: United States 1986–1990. Morbidity and Mortality Weekly Report 1994;43:810–811.
Cockerell OC, Eckle I, Goodridge DM. ander JW, Shorvon SD. Epilepsy in a population of 6000 re-examined: secular trends in first attendance rates, prevalence, and prognosis. J Neurol Neurosurg Psychiatry 1995;58:570–576.
De la Court A, Breteler MM, Meinardi H, Hauser W, Hofman A. Prevalence of epilepsy in the elderly: the Rotterdam study. Epilepsia 1996; 37: 141–147.
DosSantos SI. Cancer Epidemiology: Principles and Methods. Lyon France: WHO-IARC, 1999:82.
Fong GC, Mak W, Cheng TS, Chan KH, Fong JK, Ho SL. A prevalence study of epilepsy in Hong Kong. Hong Kong Medical Journal 2003;9:252–257.
Forsgren L. Prevalence of epilepsy in adults in Northern Sweden. Epilepsia 1992;33:450–458.
Forsgren L, Beghi E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe: a systematic review. European Journal of Neurology 2005;12:245–253.
Freitag CM, May TW, Pfafflin M, et al. Incidence of epilepsies and epileptic syndrome in children and adolescents: a population-based prospective study in Germany. Epilepsia 2001;42:979–985.
Gallitto G, Serra S, La Spina P, et al. Prevalence and Characteristics of Epilepsy in the Aeolian Islands. Epilepsia 2005;46:1828–1835.
Gekht AB, Kurkina IV, Lokshina OB, et al. An epidemiological study of epilepsy in Moscow (in Russian). Zh. Neurol. Psikhiatrii Imeni SS Korsak 1999;99:51–54.
Giuliani G, Terziani S, Senigaglia AR, Luccioni G, Foschi N, Maffei C. Epilepsy in an Italian community as assessed by a survey for prescriptions of antiepileptic drugs: epidemiology and patterns of care. Acta Neurol Scand 1992;85:23–31.
Gracia FJ, Loo S, Castillo L. Epidemiology of epilepsy in Guaymi Indians from Bocas del Toro province, Republic of Panama. Epilepsia 1990;31:718–723.
Granieri E, Rosati G, Tola R, et al. A descriptive study of epilepsy in the district of Copporo, Italy, 1964–1978. Epilepsia 1983;24:502–514.
Gudmundsson G. Epilepsy in Iceland: a clinical and epidemiologic investigation. Acta Neurol Scand 1963; 43(Suppl. 25):1–124.
Guvener A, Işık A, Ilbars Z. Epidemiological, clinical and socio-cultural aspects of epilepsy as determined by a community-based survey in Central Anatolia. Neurology and Public Health. Reports of a WHO Meeting (Eds. Kirbas D, Leonardi M). Istanbul, 1995;128–140.
Haerer AF, Anderson DW, Schoenberg BS. Prevalence and clinical features of epilepsy in a biracial United States population. Epilepsia 1986;27:66–75.
Hauser WA, Hesdorffer DC. Incidence and prevalence. In: Hauser WA, Hesdorffer DC. Epilepsy: frequency, causes and consequences. New York: Demos, 1990:1–51.
Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940–1980. Epilepsia 1991;32:429–445.
Heaney DC, MacDonald BK, Everitt A, et al. Socioeconomic variation in incidence of epilepsy: prospective community based study in south east England. BMJ 2002;325:1013–1016.
ILAE. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22:489–501.
ILAE. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic Syndromes. Epilepsia 1989;30:389–399.
ILAE. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Guidelines for Epidemiologic Studies on Epilepsy. Epilepsia 1993;34:592–596.
Jallon P. ILAE Workshop Report. Epilepsy in Developing Countries. Epilepsia 1997;38:1143–1151.
Karaağaç N, Yeni N, Şenocak M, et al. Prevalence of epilepsy in Silivri, a rural area of Turkey. Epilepsia 1999;40:637–642.
Keranen T, Riekkinen PJ, Sillanpaa M. Incidence and prevalence of epilepsy in adults in eastern Finland. Epilepsia 1989;30:413–421.
Khatri IA, Iannaccone ST, Ilyas MS, Abdullah M, Saleem S. Epidemiology of epilepsy in Pakistan: review of literature. Journal of the Pakistan Medical Association 2003;53:594–597.
Kobau R, Dilorio A, Prince PH, et al. Prevalence of epilepsy and health status of adults with epilepsy in Georgia and Tennessee: behavioral risk factor surveillance system, 2002. Epilepsy and Behavior 2004;5:358–366.
Kotsopoulos IA, van Merode T, Kessels FG, de Krom MC, Knottnerus JA. Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia 2002;43:1402–1409.
Koul R, Razdan S, Motta A. Prevalence and pattern of epilepsy (Lath/Mirgi/Laran) in rural Kashmir, India. Epilepsia 1988;29:116–122.
Leach JP, Lauder R, Nicolson A, Smith DF. Epilepsy in the UK: Misdiagnosis,mistreatment, and undertreatment? The Wrexham area epilepsy project. Seizure 2005;14:514–520.
Luengo A, Para J, Colas J, et al. Prevalence of epilepsy in Northeast Madrid. Journal of Neurology 2001;248:762–767.
Macdonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and Lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain 2000;123:665–676.
McCluggage JR, Ramsey HC, Irwin WG, Dowds MF. Anticonvulsant therapy in a general practice population in Northern Ireland. J R Coll Gen Pract 1984;34:24–31.
Medina MT, Duron RM, Martinez L, et al. Prevalence, incidence, and etiology of epilepsies in rural Honduras: The Salama study. Epilepsia 2005;46:124–131.
Mendibazal JE, Salguero LF. Prevalance of epilepsy in a rural community of Guatemala. Epilepsia 1996;37:373–376.
Nicoletti A, Reggio A, Bartoloni A, et al. Prevalence of epilepsy in rural Bolivia: a door-to-door survey. Neurology 1999;53:2064–2069.
Olafsson E, Hauser WA. Prevalence of epilepsy in rural Iceland: a population-based study. Epilepsia 1999;40:1529–1534.
Onal AE, Tumerdem Y, Ozturk MK, et al. Epilepsy prevalence in a rural area in Istanbul. Seizure 2002;11:397–401.
Osuntokun BO, Adeuja AOG, Nottidge VA, et al. Prevalence of the epilepsies in Nigerian Africans: a community-based study. Epilepsia 1987a;28:272–279.
Osuntokun BO, Adeuja AO, Schoenberg BS, et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987b;75:13–21.
Oun A, Haldre S, Magi M. Prevalence of adult epilepsy in Estonia. Epilepsy Res 2003;52:233–242.
Ozdemir Z. Prevalence and clinical features of epilepsy in a rural area of Sivas province, Turkey. In: Kırbaş D, Leonardi M. Neurology and public health: reports of a WHO meeting. Istanbul, 1995;141–143.
Radhakrishnan K, Pandian JD, Santhoshkumar T, et al. Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South India. Epilepsia 2000;41:1027–1035.
Rajeh S, Awada A, Bademosi O, Ogunniyi A. The prevalence of epilepsy and other seizure disorders an Arab population: a community-based study. Seizure 2001;10:410–414.
Rocca WA, Savettieri G, Anderson DW, et al. Sicilian Neuro-Epidemiologic Study (SNES) Group. Door-to-door prevalence survey of epilepsy in three Sicilian municipalities. Neuroepidemiology 2001;20:237–241.
Rutgers MJ. Epilepsy in general practice: Dutch situation. Epilepsia 1986;27:734–738.
Rwiza HT, Kilonzo GP, Haule J, et al. Prevalence and incidence of epilepsy in Ulanga, a rural Tanzanian district: a communitybased study. Epilepsia 1992;33:1051–1056.
Sander JW. The epidemiology of epilepsy revisited. Curr Opin Neurol 2003;16:165–170.
Sander JW, Shorvon SD. Epidemiology of epilepsies. J Neurol Neurosurg Psychiatry 1996;61:433–443.
Satishchandra P, Shivaramakrishana A, Kaliaperumal VG, Schoenberg BS. Hot-Water epilepsy: a variant of reflex epilepsy in southern India. Epilepsia 1988;29:52–56.
Sato S. The epidemiological and clinico-statistical study of epilepsy in Niigata City, part 2. Clinical Neurology 1964;4:413–424.
Scheepers B, Clough P, Pickles C. The misdiagnosis of epilepsy: findings of a population study. Seizure 1998;7:403–406.
Senanayake N, Roman GC. Epidemiology of epilepsy in developing countries. Bull WHO 1993;71:247–258.
Shinnar S, O’Dell C, Berg A. Distribution of epilepsy syndromes in a cohort of children prospectively monitored from the time of their first unprovoked seizure. Epilepsia 1999;40:1378–1383.
Shorvon SD, Farmer PJ. Epilepsy in developing countries: a review of epidemiologic, sociocultural, and treatment aspects. Epilepsia 1988;29(suppl 1):36–54.
Sridharan R, Radhakrishnan Ki Ashok PP, Mousa ME. Epidemiological and clinical study of epilepsy in Benghazi, Libya. Epilepsia 1986;27:60–65.
Sridharan R, Murthy BN. Prevalence and Pattern of epilepsy in India. Epilepsia 1999;40:631–636.
Tellez-Zenteno JF, Pondal-Sordo M, Matijevic S, Wiebe S. National and regional prevalence of self-reported epilepsy in Canada. Epilepsia 2004;45:1623–1629.
TNCBS. The official sources published yearly by the Turkish National Central Bureau of Statistics. Statistical yearbook, 61-Trabzon, 2003.
TNCBC. Turkish National Central Bureau of Census. Population Census, (2000) General Population Characteristics. TURKSTAT (Turkish Statistical Institute): Available at www.turkstat.gov.tr
Topalkara K, Akyüz A, Sümer H. A study on epilepsy prevalence in Sivas city centre performed with stratified sampling method. Epilepsia 1999;5:24–29 (In Turkish).
Velez A and Eslava-Cobos J. Epilepsy in Colombia: Epidemiologic profile and classification of epileptic seizures and syndromes. Epilepsia 2006;47:193–201.
Waaler PE, Blom BH, Skeidsvoll H, Mykletun A. Prevalence, classification, and severity of epilepsy in children in western Norway. Epilepsia 2000;41:802–810.
Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology 2003;60:1544–1545.
Wiebe S, Belhouse D, Fallahay C, Eliasziw M. Burden of epilepsy: the Ontario Health Survey. Canadian Journal of Neurological Science 1999;26:263–270.
World Health Organization Protocol. Epidemiologic studies of neurological disorders. Geneva: WHO, 1981.
Wright J, Pickard N, Whitfield A, Hakin N. A population-based study of theprevalence, clinical characteristics and effect of ethnicity in epilepsy. Seizure 2000;9:309–313.
Yalçın AD, Toydemir HE, Forta H. Hot water epilepsy: Clinical and electroencephalographic features of 25 cases. Epilepsy & Behavior 2006;9:89–94.
Zarrelli MM, Beghi E, Rocca WA, Hauser WA. Incidence of epileptic syndromes in Rochester, Minnesota: 1980–1984. Epilepsia 1999;40:1708–1714.
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Velioglu, S.K., Bakirdemir, M., Can, G. et al. Prevalence of epilepsy in northeast Turkey. Epileptic Disord 12, 22–37 (2010). https://doi.org/10.1684/epd.2010.0298
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DOI: https://doi.org/10.1684/epd.2010.0298