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Epidemiological profile of rosacea in dermatology outpatient clinics in Brazil: an observational report from the Brazilian study group on rosacea

  • Clinical Rreport
  • Published:
European Journal of Dermatology

Abstract

Background

Rosacea prevalence varies worldwide and there is a lack of information in Brazil.

Objectives

To describe the epidemiological profile of rosacea in subjects who consulted in dermatological outpatient clinics in Brazil.

Materials & Methods

A cross-sectional study was conducted in 13 dermatological outpatient clinics across the country. Patients with rosacea diagnosis were eligible for the study according to the investigator’s clinical assessment. Clinical, social and demographic data were collected. The overall and regional rosacea prevalence was calculated, and association with baseline characteristics was analysed.

Results

A total of 3,184 subjects were enrolled, and rosacea prevalence was 12.7%. The southern region of Brazil presented a higher prevalence, followed by the southeast. The subjects in the rosacea group were older than those without rosacea (52.5 ± 14.9 vs. 47.5 ± 17.5; p<0.001). Moreover, the rosacea group was associated with Fitzpatrick’s phototypes I and II, Caucasian ethnicity, a family history of rosacea, and facial erythema, however, no association with gender was found. The most prevalent clinical sign and clinical subtype in rosacea patients were erythema and erythematotelangiectatic, respectively.

Conclusion

Rosacea is highly prevalent in Brazil, mostly in the southern region, associated with phototypes I and II and a family history.

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References

  1. Rainer BM, Kang S, Chien AL. Rosacea: epidemiology, pathogenesis, and treatment. Dermatoendocrinol 2017; 9: e1361574.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tan J, Berg M. Rosacea: current state of epidemiology. J Am Acad Dermatol 2013; 69: S27–35.

    Article  PubMed  Google Scholar 

  3. Wilkin J, Dahl M, Detmar M, et al. Standard classification of rosacea: report of the National Rosacea Society expert committee on the classification and staging of rosacea. J Am Acad Dermatol 2002; 46: 584–87.

    Article  PubMed  Google Scholar 

  4. de Oliveira CMM, Almeida LMC, Bonamigo RR, de Lima CWG, Bagatin E. Consensus on the therapeutic management of rosacea–Brazilian Society of Dermatology. An Bras Dermatol 2020; 95: 53–69.

    Article  Google Scholar 

  5. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol 2018; 179: 282–89.

    CAS  PubMed  Google Scholar 

  6. Tan J, Singh B, Song Y, et al. Rosacea treatments: current standards and additional options. Dermatological Rev 2021: 1–22.

  7. Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol 2013; 69: S15–26.

    Article  CAS  PubMed  Google Scholar 

  8. Steinhoff M, Buddenkotte J, Aubert J, et al. Clinical, cellular, and molecular aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc 2011; 15: 2–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Holmes AD, Steinhoff M. Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics. Exp Dermatol 2017; 26: 659–67.

    Article  CAS  PubMed  Google Scholar 

  10. Wang Y, Chi C-C. Rosacea, germs, and bowels: a review on gastrointestinal comorbidities and gut-skin axis of rosacea. Adv Ther 2021; 38: 1415–24.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Woo YR, Han YJ, Kim HS, Cho SH, Lee JD. Updates on the risk of neuropsychiatric and gastrointestinal comorbidities in rosacea and its possible relationship with the gut–brain–skin axis. Int J Mol Sci 2020; 21: 1–13.

    Article  Google Scholar 

  12. Abram K, Silm H, Oona M. Prevalence of rosacea in an Estonian working population using a standard classification. Acta Derm Venereol 2010; 90: 269–73.

    Article  PubMed  Google Scholar 

  13. Tan J, Schöfer H, Araviiskaia E, Audibert F, Kerrouche N, Berg M. Prevalence of rosacea in the general population of Germany and Russia–The RISE study. J Eur Acad Dermatol Venereol 2016; 30: 428–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Xie HF, Huang YX, He L, et al. An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations. PeerJ 2017; 5: e3527.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Egeberg A, Fowler JF, Gislason GH, Thyssen JP. Nationwide assessment of cause-specific mortality in patients with rosacea: a cohort study in Denmark. Am J Clin Dermatol 2016; 17: 673–79.

    Article  PubMed  Google Scholar 

  16. Wilkin J, Dahl M, Detmar M, et al. Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol 2004; 50: 907–12.

    Article  PubMed  Google Scholar 

  17. Tan J, Almeida LMC, Bewley A, et al. Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel. Br J Dermatol 2017; 176: 431–38.

    Article  CAS  PubMed  Google Scholar 

  18. Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988; 124: 869–71.

    Article  CAS  PubMed  Google Scholar 

  19. Khaled A, Hammami H, Zeglaoui F, et al. Rosacea: 244 Tunisian cases. Tunisie Medicale 2010; 88: 597–601.

    PubMed  Google Scholar 

  20. Doe PT, Asiedu A, Acheampong JW, Payne CMR. Skin diseases in Ghana and the UK. Int J Dermatol 2001; 40: 323–26.

    Article  CAS  PubMed  Google Scholar 

  21. Rueda LJ, Motta A, Pabón JG, et al. Epidemiology of rosacea in Colombia. Int J Dermatol 2017; 56: 510–13.

    Article  PubMed  Google Scholar 

  22. Wienholtz NKF, Christensen CE, Haugaard JH, et al. Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO). BMJ Open 2020; 10: e039445.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Breton AL, Truchetet F, Véran Y, et al. Prevalence analysis of smoking in rosacea. J Eur Acad Dermatology Venereol 2011; 25: 1112–13.

    Article  CAS  Google Scholar 

  24. Yuan X, Yin D. Association between rosacea and smoking: a systematic review and meta-analysis. Dermatol Ther 2021; 34: e14747.

    Article  PubMed  Google Scholar 

  25. Li S, Cho E, Drucker AM, Qureshi AA, Li W-Q. Alcohol intake and risk of incident rosacea in US women. J Am Acad Dermatol 2017; 76: 1061.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Aldrich N, Gerstenblith M, Fu P, et al. Genetic vs environmental factors that correlate with rosacea: a cohort-based survey of twins. JAMA Dermatol 2015; 151: 1213–19.

    Article  PubMed  Google Scholar 

  27. Drago F, Col E De, Agnoletti AF, et al. The role of small intestinal bacterial overgrowth in rosacea: a 3-year follow-up. J Am Acad Dermatol 2016; 75: e113–115.

    Article  PubMed  Google Scholar 

  28. Drago F, Ciccarese G, Herzum A, Rebora A, Parodi A. Rosacea and alcohol intake. J Am Dermatol 2018; 78: e25.

    Article  Google Scholar 

Download references

Acknowledgments

The authors thank Maria Catalina Gavilanes Coloma for assistance in writing the article, Drs Cristhine Kamamoto and Josy Davidson for editorial assistance, and Ananda Quadros Campos and Meirenice Silva for clinical study assistance.

Author information

Authors and Affiliations

  1. Hospital do Servidor Público Municipal de São Paulo, Rua Castro Alves 60, 5° andar sala 52, São Paulo, SP, 01532001, Brazil

    Maria Victoria Suarez

  2. Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Av. Pedro Teixeira, s/n, Manaus, AM, 69040-000, Brazil

    Fábio Francesconi & Valeska Albuquerque Francesconi

  3. Centro de Dermatologia Dona Libania, R. Pedro I, 1033, Fortaleza, CE, 60035-100, Brazil

    Heitor Gonçalves & Maria Araci De Andrade Pontes

  4. Hospital São Lucas da PUCRS, Av. Ipiranga, 6681, Porto Alegre, RS, 90619-900, Brazil

    Taciana Dal’Forno

  5. Hospital Regional da Asa Norte, Setor Médico Hospitalar Norte Q 2, Brasília, DF, 70710-100, Brazil

    Beatriz De Medeiros Ribeiro

  6. Universidade Federal do Paraná, Rua João Negrão, 280, Curitiba, Paraná, 80010-200, Brazil

    Fabiane Mulinari-Brenner

  7. Hospital Universitário de Brasília, Setor de Grandes Áreas Norte 605, Brasília, DF, 70840-901, Brazil

    Izelda Maria Carvalho Costa & Amadeu José Rodrigues Queiroz

  8. Serviço de Dermatologia do Hospital Universitário Walter Cantidio-UFCE, Rua Pastor Samuel Munguba, 1290, Fortaleza, CE, 60430-370, Brazil

    José Wilson Accioly Filho

  9. Fundação do ABC - Faculdade de Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, 09060-870, Brazil

    Marisa Gonzaga Cunha

  10. Universidade Federal da Bahia - Hospital Universitário Professor Edgar Santos, R. Dr. Augusto Viana, s/n, Salvador, BA, 40110-060, Brazil

    Ivanise Follador & Vitória Rego

  11. Serviço de Dermatologia do Hospital Federal de Bonsucesso, Av. Londres, 616 - prédio 6 - 2° andar, Rio de Janeiro, RJ, 21041-030, Brazil

    Paulo Cotrim & Beatrix Saboia Zink

  12. Setor de Dermatologia do Hospital de Força Aérea do Galeão, Estrada do Galeão, 4101, Rio de Janeiro, RJ, 21941-353, Brazil

    Juliane Rócio Neves & Lidiane Pereira Marques

  13. Universidade Federal de Pernambuco - Serviço de Dermatologia, Av. Prof. Moraes Rego, 1235, Recife, PE - Brazil, 50670-901, Brazil

    Maria De Fátima De Medeiros Brito

Authors
  1. Maria Victoria Suarez
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  2. Fábio Francesconi
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  3. Heitor Gonçalves
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  4. Taciana Dal’Forno
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  5. Beatriz De Medeiros Ribeiro
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  6. Fabiane Mulinari-Brenner
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  7. Izelda Maria Carvalho Costa
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  8. José Wilson Accioly Filho
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  9. Marisa Gonzaga Cunha
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  10. Ivanise Follador
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  11. Paulo Cotrim
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  12. Juliane Rócio Neves
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  13. Maria De Fátima De Medeiros Brito
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  14. Valeska Albuquerque Francesconi
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  15. Maria Araci De Andrade Pontes
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  16. Amadeu José Rodrigues Queiroz
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  17. Vitória Rego
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  18. Beatrix Saboia Zink
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  19. Lidiane Pereira Marques
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Corresponding author

Correspondence to Maria Victoria Suarez.

Additional information

Financial support

From Galderma.

Conflicts of interest

Dr Maria Victória Suarez Restrepo, Dr. Fabio Francesconi, Dr. Beatriz de Medeiros Ribeiro, Dr. Fabiane Brenner, Dr. José Wilson Accioly Filho, Dr. Juliane Rocio Neves, Dr. Maria de Fátima Medeiros Brito, Dr. Amadeu Queiroz: funding from Galderma. Dr. Taciana Dal’ Forno Dini: member of Galderma advisory board and speaker for Galderma. Dr. Heitor de Sá Gonçalves, Dr. Izelda Maria Carvalho Costa, Dr. Marisa Gonzaga da Cunha, Dr. Paulo Roberto Cotrim de Souza, Dr. Ivonise Follador, Dr. Valeska Albuquerque Francesconi, Dr Araci Pontes, Dr Vitória Rego, Dr. Beatrix Saboia Zink, Dr. Lidiane Marques: none.

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Victoria Suarez, M., Francesconi, F., Gonçalves, H. et al. Epidemiological profile of rosacea in dermatology outpatient clinics in Brazil: an observational report from the Brazilian study group on rosacea. Eur J Dermatol 33, 6–11 (2023). https://doi.org/10.1684/ejd.2023.4405

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  • DOI: https://doi.org/10.1684/ejd.2023.4405

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