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Marjolin ulcers after cultured epidermal autograft in severely burned patients: a rare case series and literature review

  • Clinical report
  • Published:
European Journal of Dermatology

Abstract

Background

The advent of tissue engineering and the clinical applications with cultured epidermal autograft (CEA) have improved the prognosis of severely burned patients. Marjolin ulcers (MUs) are a well-known complication of burns. These malignant neoplasm transformations of burn scars are usually squamous cell carcinomas with a higher incidence of regional metastases. Radical surgery remains the treatment of choice.

Objectives

To identify cases of malignant transformation occurring at sites of CEA in a cohort of 68 massively burned patients.

Materials & Methods

A retrospective single-centre study was performed from April 2017 to June 2019 at the Military Hospital of Clamart (France). A total of 34 patients treated between 1991 and 2013 (including one post-mortem) were included.

Results

Four cases of squamous cell carcinoma occurred in areas previously covered by CEA. The data from clinical and histopathological examination as well as treatment modalities are presented. One patient died as a result of the evolution of his squamous cell carcinoma, and two others required salvage amputation due to locoregional recurrence. The prevalence of these CEA-MUs is estimated at between 5.9% and 11.7% and the person-time incidence rate of CEA-related MUs is about 5.9 per 1,000 persons-years. In our study, the average time to malignant transformation seems considerably shortened (32–35 years for “classic burn MU” versus 15.7 years for CEA-MU).

Conclusion

This first documented case series of CEA-MUs demonstrates the need to inform caregivers and educate patients. Further studies are needed to specify the true incidence of CEA-graft site malignancy.

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Acknowledgment and disclosures

Acknowledgments: We would like to thank Dr. N’Guyen Anhtuan (Pathology Department, Begin Military Hospital, Saint Mandé, France), Dr. Benali-Abdeellaoui Khadija (Nuclear Medicine Department, Bichat Hospital, Paris, France), Dr Pinatel Baptiste (Plastic and Reconstructive Surgery, Saint Luc and Saint Joseph Hospital, Lyon, France), Dr Trouillas Marina (PhD, IRBA/French Armed-forces Biomedical Research Institute, Clamart, France) and Dr Jacob Louis (Physical and Rehabilitation Medicine Department, Garches Hospital, France) for their proofreading and scientific contribution.

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Authors and Affiliations

  1. Plastic and reconstructive surgery Burn Unit, Percy military Hospital, Clamart, France

    Arnaud Baus, Chafik Keilani, Claire Sophie Bich, Michel Brachet, Eric Bey & Patrick Duhamel

  2. Department of Dermatology, Bichat Hospital, Paris, France

    Florence Brunet-Possenti

  3. Pathology department, Bichat Hospital, Paris, France

    Lydia Deschamps

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  1. Arnaud Baus
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  2. Chafik Keilani
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  3. Florence Brunet-Possenti
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  4. Claire Sophie Bich
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  6. Michel Brachet
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  7. Eric Bey
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Correspondence to Arnaud Baus.

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Conflicts of interest

None of the authors has a financial interest in any of the products, devices or drugs mentioned in this manuscript. This review did not receive any funding. The opinions or assertions expressed here are the private views of the authors and are not to be considered as official or as reflecting the views of the French Defence Health Service.

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Baus, A., Keilani, C., Brunet-Possenti, F. et al. Marjolin ulcers after cultured epidermal autograft in severely burned patients: a rare case series and literature review. Eur J Dermatol 31, 759–770 (2021). https://doi.org/10.1684/ejd.2021.4174

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  • DOI: https://doi.org/10.1684/ejd.2021.4174

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