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Comparison of quality of life between melanoma and non-melanoma skin cancer patients

  • Clinical Report
  • Published:
European Journal of Dermatology



The impact of skin cancers on patients’ health-related quality of life (HRQoL) is often overlooked, and direct comparisons between melanoma and non-melanoma skin cancer (NMSC) are rare.


The aim of this study was to compare HRQoL in patients with melanoma and NMSC.

Materials and Methods

Participants were unselected, consecutive adult patients with a diagnosis of melanoma at the time of wide excision, or NMSC at the time of surgery. HRQoL was measured using the two scales of Skindex-17. The 12-item General Health Questionnaire (GHQ-12) was used to identify patients with possible anxiety or depression.


The study population included 433 patients: 65 with melanoma and 368 with NMSC. Skindex-17 symptom mean scores were higher in NMSC than in melanoma patients. Melanoma patients had significantly higher scores for the item “feeling depressed”. The percentage of GHQ-12 cases (with possible non-psychotic, minor psychiatric disorders) was significantly higher in patients with melanoma (32.8%) compared to NMSC patients (8.7%).


NMSC places a greater burden of symptoms on patients than melanoma, while the psychological impact of melanoma is higher.

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Correspondence to Francesca Sampogna.

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Sampogna, F., Paradisi, A., Iemboli, M.L. et al. Comparison of quality of life between melanoma and non-melanoma skin cancer patients. Eur J Dermatol 29, 185–191 (2019).

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