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Effects of Curcuma extract and visible light on adults with plaque psoriasis



We conducted a phase IV randomized, double-blind, placebo-controlled, pilot clinical trial to investigate the safety and efficacy of oral curcumin together with local phototherapy in patients with plaque psoriasis.

Materials and methods

Patients with moderate to severe psoriasis received Curcuma extract orally with real visible light phototherapy (VLRT) or simulated visible light phototherapy (VLST) in the experimental area, while the rest of the body surface was treated with ultraviolet A (UVA) radiation. The endpoints were the number of responders and the temporal course of the response. The secondary outcomes were related to safety and adverse events.


Twenty-one patients were included in the study. In the intention-to-treat analysis, no patients included in the VLRT group showed “moderate” or “severe” plaques after the treatment, in contrast to the patients included in the VSLT group (p<0.01). Parallelisms in the evolution of PGA, BSA, and PASI scores were observed in the two groups following the treatment. At the end of the study period, 76% of all patients showed a response in the BSA exposed to UVA. Lesions on the experimental area showed a response in 81% of the patients in the VLRT group and 30% of the patients in the VLST group. There were no study-related adverse events that necessitated participant withdrawal.


The results suggested that moderate to severe plaque psoriasis should showa therapeutic response to orally administered Curcuma if activated with visible light phototherapy, a new therapeutic method that would be safer for patients than existing treatments.

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Psoralen associated with Ultraviolet A radiation


Ultraviolet radiation


Ultraviolet A radiation


Ultraviolet B radiation


Visible light real treatment


Visible light simulated treatment


Body Surface Area Affected


Physician Global Assessment


Psoriasis Area Severity Index


  1. Lázaro P, Suárez R. Actualización en el tratamiento de la psoriasis. Inf Ter Sist Nac Salud 2001; 25: 105–10.

    Google Scholar 

  2. Stern RS. Psoralen and ultraviolet a light therapy for psoriasis. N Engl J Med 2007; 357: 682–90.

    Article  CAS  PubMed  Google Scholar 

  3. Menter AB, Gottlieb A, Feldman SR, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol 2008; 58: 826–50.

    Article  PubMed  Google Scholar 

  4. Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol 2007; 595: 343–57.

    Article  PubMed  Google Scholar 

  5. Dujic J, Kippenberg S, Hoffmann S, et al. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol 2007; 127: 1992–2000.

    Article  CAS  PubMed  Google Scholar 

  6. Dujic J, Kippenberger S, Ramirez-Bosca A, et al. Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. Int J Cancer 2009; 124: 1422–8.

    Article  CAS  PubMed  Google Scholar 

  7. Miquel J, Bernd A, Sempere JM, Díaz-Alperi J, Ramírez-Boscá A. The Curcuma antioxidants: pharmacological effects and prospects for future clinical use. Arch Gerontol Geriatr 2002; 34: 34–46.

    Article  Google Scholar 

  8. Bernd A, Theilig C, Kippenberg S, et al. An extract of Curcuma longa exerts antioxidative, antiinflamatory and antiproliferative effects on human keratinocytes in vitro. J Invest Dermatol 1997; 109: 460.

    Google Scholar 

  9. Bernd A, Theilig C, Kippenberg S, et al. Effects of Curcuma longa extract on the expression of proinflammatory citokines. Skin Pharmacol Apll Skin Physiol 2000; 13: 226.

    Google Scholar 

  10. Asín-LLorca M, Ramírez-Boscá A, Miquel J, et al. Ensayo clínico piloto no controlado de eficacia de 600 mg/día de Extracto de Curcuma estandarizado al 12% en curcumina en el tratamiento de pacientes con psoriasis crónica en placas moderada-grave. 2006; EUDRACT N° 2006-003395-35.

    Google Scholar 

  11. Kurd SK, Smith N, Voorhees AV, et al. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial. J Am Acad Dermatol 2008; 58: 625–31.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Tope WD, Shaffer JJ. Photodynamic treatment; in Bolognia JL, Jorizzo JL, Rapini RP (eds): Dermatology Elsevier, 2005.

  13. Guideline on clinical investigation on medical products indicated for the treatment of psoriasis. [Internet]. CHMP/EWP/2454/02 2011 Mar 8; Available from:

  14. Henseler T, Wolff K, Honigsmann H, Christopher E. The European PUVA study: A cooperative study among 18 european centres. Lancet 1981; 1: 853–7.

    Article  CAS  PubMed  Google Scholar 

  15. Sivanesan SP, Gattu S, Hong J, et al. Randomized, double-blind, placebo-controlled evaluation of the efficacy of oral psoralen plus ultraviolet A for the treatment of plaque-type psoriasis using the Psoriasis Area Severity Index score (improvement of 75% or greater) at 12 weeks. J Am Acad Dermatol 2009; 65: 793–8.

    Article  Google Scholar 

  16. Lin JK, Pan MH, Lin-Shiau SY. Recent studies on the biofunctions and biotransformations of curcumin. Biofactors 2000; 10: 153–8.

    Article  Google Scholar 

  17. Mashewari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006; 7: 2081–7.

    Article  Google Scholar 

  18. Sikora E, Bielak-Zmijewska A, Magalska A, et al. Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase activated DNA endonuclease in human Jurkat cells. Mol Cancer Ther 2006; 52: 927–34.

    Article  Google Scholar 

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Correspondence to Miguel Carrion-Gutierrez.

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Carrion-Gutierrez, M., Ramirez-Bosca, A., Navarro-Lopez, V. et al. Effects of Curcuma extract and visible light on adults with plaque psoriasis. Eur J Dermatol 25, 240–246 (2015).

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  • psoriasis
  • Curcuma longa extract
  • visible light
  • phototherapy