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Linear IgA/IgG bullous dermatosis reacts with multiple laminins and integrins

  • Investigative Report
  • Published:
European Journal of Dermatology Aims and scope

Abstract

Background

Since the original description by Zone et al in 1994, the disease entity and target antigens in linear IgA/IgG bullous dermatosis (LAGBD) have not been clarified in 20 years.

Objectives

To determine autoantibodies and autoantigens in a new LAGBD case which showed atypical clinical and histopathological findings without apparent mucosal involvement.

Materials and Methods

We performed various indirect immunofluorescence and immunoblotting studies.

Results

Indirect immunofluorescence of 1M NaCl-split skin showed IgG and IgA reactivity with both epidermal and dermal sides. Immunoblotting studies using various antigen sources revealed circulating IgG and IgA antibodies reactive with laminin-332, laminin-γ1 and integrin α6β4 in various patterns. Absorption study using recombinant proteins of laminin-γ1 indicated that the patient serum reacted with different epitopes between laminin-γ1 and laminin-γ2.

Conclusions

This study presented for the first time a LAGBD patient with IgG and IgA antibodies to various laminins and integrins.

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Authors and Affiliations

  1. Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan

    Xiaoguang Li, Atsunari Tsuchisaka, Hua Qian, Kwesi Teye, Norito Ishii, Ryosuke Sogame & Takashi Hashimoto

  2. Department of Dermatology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan

    Kazutoshi Harada, Daiki Nakagomi & Shinji Shimada

  3. Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Chiharu Tateishi

  4. Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi, Japan

    Yoshiaki Hirako

Authors
  1. Xiaoguang Li
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  2. Atsunari Tsuchisaka
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  3. Hua Qian
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  4. Kwesi Teye
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  5. Norito Ishii
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  6. Ryosuke Sogame
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  7. Kazutoshi Harada
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  8. Daiki Nakagomi
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  9. Shinji Shimada
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  10. Chiharu Tateishi
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  11. Yoshiaki Hirako
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  12. Takashi Hashimoto
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Corresponding author

Correspondence to Takashi Hashimoto.

Additional information

These three authors contributed equally to this study.

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Li, X., Tsuchisaka, A., Qian, H. et al. Linear IgA/IgG bullous dermatosis reacts with multiple laminins and integrins. Eur J Dermatol 25, 418–423 (2015). https://doi.org/10.1684/ejd.2015.2555

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  • DOI: https://doi.org/10.1684/ejd.2015.2555

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