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Epicutaneous exposure to proteins and skin immune function

  • Review Article
  • Published:
European Journal of Dermatology

Abstract

The skin has a sophisticated and highly orchestrated immune system. The ability of proteins encountered at skin surfaces to access that immune system remains controversial, however. In this article the question considered is whether proteins encountered epicutaneously (on the skin) at abraded or tape-stripped skin surfaces, but also at sites where the skin is intact, can engage with the cutaneous immune system to provoke and regulate responses. The available evidence suggests that epicutaneous exposure to foreign proteins is able to elicit immune and allergic responses, and that encounter with protein via this route may favour the development of selective Th2 responses and allergic sensitisation. It is also clear that proteins can modify immunological function when delivered topically and that intact skin may provide an effective route of exposure for active immunotherapy of allergic disease. An appreciation that epicutaneously applied proteins can interact with the skin immune system, even when delivered at intact skin sites, opens up important opportunities for immunotherapy, local immune modulation and the treatment of inflammatory skin diseases. It also indicates that this route of exposure must be considered as part of the safety assessment and risk management of protein-induced allergic sensitisation.

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Author information

Authors and Affiliations

  1. Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

    Ian Kimber & Rebecca J. Dearman

  2. Centre for Dermatology Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

    Christopher E. M. Griffiths

  3. DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire, UK

    David A. Basketter

  4. St John’s Institute of Dermatology, Kings College, St Thomas’ Hospital, London, UK

    John P. McFadden

Authors
  1. Ian Kimber
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  2. Christopher E. M. Griffiths
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  3. David A. Basketter
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  4. John P. McFadden
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  5. Rebecca J. Dearman
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Corresponding author

Correspondence to Ian Kimber.

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Kimber, I., Griffiths, C.E.M., Basketter, D.A. et al. Epicutaneous exposure to proteins and skin immune function. Eur J Dermatol 24, 10–14 (2014). https://doi.org/10.1684/ejd.2013.2187

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  • DOI: https://doi.org/10.1684/ejd.2013.2187

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