European Journal of Dermatology

, Volume 28, Issue 5, pp 661–667 | Cite as

Positive margins after surgical excision of locoregional cutaneous melanoma metastasis and their impact on patient outcome

  • Barbara BregeonEmail author
  • Jean-Michel Nguyen
  • Emilie Varey
  • Gaelle Quereux
  • Mélanie Saint-Jean
  • Lucie Peuvrel
  • Amir Khammari
  • Brigitte Dreno
Clinical report



For melanoma patients, surgery is a standard treatment for locoregional skin metastasis (LSM).


To assess the frequency, and risk factors for positive margins after excision of LSM and their impact on patient overall survival (OS) and progression-free survival (PFS).

Materials & methods

A monocentric, retrospective observational study was performed including 87 patients with LSM who had undergone surgical excision.


Positive margins were found in 45% of patients after excision. After additional excision, 28% of patients still had positive margins. Interestingly, there was no difference in PFS or OS for clear margins after the first or additional excision or for margins that remained positive without additional excision. LSM size was the only identified predictive factor for positive margins.


This is the first reported study investigating the frequency of, and risk factors for positive margins of cutaneous LSM, which raises the question of whether additional excision should be performed following positive margin excision.

Key words

melanoma locoregional skin metastasis surgery positive margin overall survival progression-free survival risk factor 


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Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Barbara Bregeon
    • 1
    Email author
  • Jean-Michel Nguyen
    • 1
    • 2
  • Emilie Varey
    • 1
    • 3
  • Gaelle Quereux
    • 1
    • 3
  • Mélanie Saint-Jean
    • 1
    • 3
  • Lucie Peuvrel
    • 1
    • 3
  • Amir Khammari
    • 1
    • 3
  • Brigitte Dreno
    • 1
    • 3
  1. 1.Service de dermatologie, Hôtel-DieuCHU de NantesNantesFrance
  2. 2.PIMESP-SEBSaint-Jacques HospitalNantesFrance
  3. 3.Service de dermatologie, CIC 1413, CRCINA INSERM 1232CHU de NantesNantesFrance

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