European Journal of Dermatology

, Volume 28, Issue 5, pp 704–705 | Cite as

Nevus cells of cardiofaciocutaneous syndrome bear BRAF germ-line and somatic double mutations

  • Tokimasa HidaEmail author
  • Sayuri Sato
  • Masae Okura
  • Hisashi Uhara

Supplementary material

40699_2019_3375_MOESM1_ESM.pdf (363 kb)
Supplementary material, approximately 364 KB.


  1. 1.
    Sato S, Hida T, Okura M, Ishikawa A, Yamashita T. An adult case of cardiofaciocutaneous syndrome with BRAF mutation. Eur J Dermatol 2017; 27: 412–3.Google Scholar
  2. 2.
    Bennett DC. Genetics of melanoma progression: the rise and fall of cell senescence. Pigment Cell Melanoma Res 2015; 29: 122–40.CrossRefGoogle Scholar
  3. 3.
    Ribero S, Glass D, Bataille V. Genetic epidemiology of melanoma. Eur J Dermatol 2016; 26: 335–9.Google Scholar
  4. 4.
    Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600–associated senescence–like cell cycle arrest of human naevi. Nature 2005; 436: 720–4.CrossRefGoogle Scholar
  5. 5.
    Patton EE, Widlund HR, Kutok JL, et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 2005; 15: 249–54.CrossRefGoogle Scholar
  6. 6.
    Urtatiz O, Samani AMV, Kopp JL, Van Raamsdonk CD. Rapid melanoma induction in mice expressing oncogenic BrafV600E using Mitf–cre. Pigment Cell Melanoma Res 2018; 31: 541–4.CrossRefGoogle Scholar
  7. 7.
    Kumar SM, Dai J, Li S, et al. Human skin neural crest progenitor cells are susceptible to BRAFV600E–induced transformation. Oncogene 2014; 33: 832–41.CrossRefGoogle Scholar
  8. 8.
    Chen FW, Tseng D, Reddy S, Daud AI, Swetter SM. Involution of eruptive melanocytic nevi on combination BRAF and MEK inhibitor therapy. JAMA Dermatol 2014; 150: 1209–12.CrossRefGoogle Scholar
  9. 9.
    Su F, Viros A, Milagre C, et al. RAS mutations in cutaneous squamous–cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 2012; 366: 207–15.CrossRefGoogle Scholar
  10. 10.
    Zimmer L, Hillen U, Livingstone E, et al. Atypical melanocytic proliferations and new primary melanomas in patients with advanced melanoma undergoing selective BRAF inhibition. J Clin Oncol 2012; 30: 2375–83.CrossRefGoogle Scholar

Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Tokimasa Hida
    • 1
    Email author
  • Sayuri Sato
    • 1
  • Masae Okura
    • 1
  • Hisashi Uhara
    • 1
  1. 1.Department of DermatologySapporo Medical University School of MedicineSapporoJapan

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