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European Journal of Dermatology

, Volume 28, Issue 3, pp 343–350 | Cite as

Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging

  • Ediléia Bagatin
  • Heitor de Sá Gonçalves
  • Maurício Sato
  • Luiz Maurício Costa Almeida
  • Helio Amante Miot
Therapy

Abstract

Background

Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging.

Objectives

To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin.

Materials & Methods

An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0.3% gel or tretinoin 0.05% cream. Subjects were evaluated at Weeks 1, 4, 8, 12, 16, 20 and 24, based on clinical signs of cutaneous photoaging, histopathological and digital morphometric findings, as well as safety and tolerability.

Results

A comparison of clinical efficacy showed that both treatments did not differ significantly regarding clinical evaluation of the following criteria: global cutaneous photoaging, periorbital wrinkles, ephelides/melanosis, forehead wrinkles, and AK.

Conclusion

Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.

Key words

adapalene melanosis photoaging retinoid tretinoin wrinkles 

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Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Ediléia Bagatin
    • 1
    • 2
  • Heitor de Sá Gonçalves
    • 3
  • Maurício Sato
    • 4
  • Luiz Maurício Costa Almeida
    • 5
    • 6
  • Helio Amante Miot
    • 7
  1. 1.Department of DermatologyFederal University of São PauloSão PauloBrazil
  2. 2.Translational Medicine Post-Graduation ProgramFederal University of São PauloSão PauloBrazil
  3. 3.Dona Libânia Dermatology center, Department of HealthCearáBrazil
  4. 4.Federal University of ParanáParanáBrazil
  5. 5.Department of DermatologyMedical Sciences CollegeBelo HorizonteBrazil
  6. 6.Preceptor of the medical residency of the Santa CasaSão PauloBrazil
  7. 7.Department of DermatologyFMB-UnespSão PauloBrazil

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