European Cytokine Network

, Volume 29, Issue 3, pp 112–120 | Cite as

Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis

  • Jean-Philippe BastardEmail author
  • Soraya Fellahi
  • Étienne Audureau
  • Richard Layese
  • Françoise Roudot-Thoraval
  • Carole Cagnot
  • Valérie Mahuas-Bourcier
  • Angela Sutton
  • Marianne Ziol
  • Jacqueline Capeau
  • Pierre Nahon
  • ANRS CO12 CirVir Group
Original Article


Background and aims

An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk.


This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis.We selected 56 HCV1-infected patients who subsequently developed HCC (cases), and 96 controls matched for age, gender and diabetes, not developing HCC after a similar period. Adipokines and immuno-inflammatory biomarkers were determined on baseline frozen serum samples. Their influence on the occurrence of HCC was assessed using a mixed logistic regression model under univariate analysis and a backward stepwise procedure under multivariate analysis.


The patients were mostly male (62.5%) with active HCV replication (83%) and had been followed for a median duration of 6.3 years during which 44.4% achieved a sustained viral response. Higher adiponectinemia levels were found in cases than in controls (P = 0.01). Levels of the immuno-inflammatory markers were similar in both groups except sTNFRII >5,000 pg/mL (52% cases versus 24% controls; P = 0.001). No marker was associated with histological steatosis. Under multivariate analysis, baseline adiponectin and sTNFRII levels were independently associated with the occurrence of HCC,alongside previous excessive alcohol intake and HCV viral load.


High baseline circulating adiponectin and sTNFRII levels were associated with an increased risk of HCC in patients with HCV1 cirrhosis, independently of their HCV replication status.

Key words

HCV hepatocellular carcinoma adipokines immuno-inflammatory biomarkers 


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Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Jean-Philippe Bastard
    • 1
    • 2
    • 3
    • 15
    Email author
  • Soraya Fellahi
    • 1
    • 2
    • 3
  • Étienne Audureau
    • 4
    • 5
  • Richard Layese
    • 4
    • 5
  • Françoise Roudot-Thoraval
    • 4
    • 5
  • Carole Cagnot
    • 6
  • Valérie Mahuas-Bourcier
    • 7
  • Angela Sutton
    • 8
    • 9
    • 10
  • Marianne Ziol
    • 11
    • 12
    • 13
  • Jacqueline Capeau
    • 2
    • 3
  • Pierre Nahon
    • 7
    • 12
    • 14
  • ANRS CO12 CirVir Group
  1. 1.AP-HP, hôpital Tenon, UF biomarqueurs inflammatoires et métaboliques, service de biochimieParisFrance
  2. 2.Sorbonne université, faculté de médecineParisFrance
  3. 3.Inserm, CRSA, UMR_S 938ParisFrance
  4. 4.AP-HP, hôpital Henri-Mondor, Public Health Department, Clinical Research Unit (URC-Mondor)CréteilFrance
  5. 5.université Paris-Est, UPEC, DHU A-TVB, IMRB-EA 7376 CEpiA (Clinical Epidemiology and Ageing Unit)CréteilFrance
  6. 6.Unit for Basic and Clinical Research on Viral HepatitisANRSParisFrance
  7. 7.AP-HP, hôpital Jean-Verdier, service d’hépatologieBondyFrance
  8. 8.CRB (Liver Disease Biobank), groupe hospitalier ParisSeine-Saint-Denis BB-0033-00027France
  9. 9.AP-HP, hôpital Jean-Verdier, service de biochimieBondyFrance
  10. 10.Inserm U1148université Paris 13BobignyFrance
  11. 11.Université Paris 13, Sorbonne Paris-CitéBobignyFrance
  12. 12.Inserm UMR_S 1162, « Génomique fonctionnelle des tumeurs solides »ParisFrance
  13. 13.APHP, hôpital Jean-Verdier, anatomie pathologiqueBondyFrance
  14. 14.Université Paris 13, Sorbonne Paris-Cité, « Équipe labellisée Ligue contre le cancer »Saint-DenisFrance
  15. 15.Hôpital Tenon, UF biomarqueurs inflammatoires et métaboliques, service de biochimie et hormonologieParis cedex 20France

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