摘要
草铵膦作为谷氨酸(Glu)的结构类似物,可以不可逆地抑制植物中谷氨酰胺合成酶(GS)和谷氨酸脱羧酶活性,从而阻止谷氨酰胺(Gln)生成,最终导致植物因氮代谢紊乱和细胞内氨积累而死亡。人误服草胺磷后也会出现相应的中毒症状,包括胃肠道症状和神经毒性。草铵膦作为最常见的致癫痫类除草剂,且无特定解毒剂,因此支持性治疗至关重要。在临床诊治过程中,如何及时有效识别草铵膦除草剂引起的神经毒性并提供适当治疗尤为关键。本文介绍了我院三名草铵膦中毒患者的主要症状,其中癫痫是主要的神经表现。随后,通过查阅相关文献,对草铵膦引发神经毒性的相关机制进行了总结,并讨论了神经毒性的预测和检测方法。
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Data availability statement
The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgments
This work was supported by the Key Research and Development Program of Zhejiang Province (No. 2019C03076), China.
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Ping WANG studied the concept and prepared the first draft of the manuscript. Congying SONG and Xuan LU made critical revisions to the article. Yuanqiang LU acquired funding, and participated in reviewing and editing the manuscript. All authors have read and approved the final manuscript, and therefore, have full access to all data relevant to the study and take responsibility for the integrity and security of such data.
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Ping WANG, Congying SONG, Xuan LU, and Yuanqiang LU declare that they have no conflict of interest.
This research was approved by the First Affiliate Hospital, School of Medicine, Zhejiang University, Hangzhou, China (No. 2022624). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013. Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this paper.
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Wang, P., Song, C., Lu, X. et al. Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning. J. Zhejiang Univ. Sci. B 25, 354–358 (2024). https://doi.org/10.1631/jzus.B2300469
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DOI: https://doi.org/10.1631/jzus.B2300469