Abstract
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.
摘要
口腔白斑是一种常见的口腔潜在恶性病变, 可恶变为口腔鳞状细胞癌, 恶性潜能较高。白斑癌变严重影响患者的生存和生活质量, 但因缺乏有效的癌变预测生物标志物, 难以对其癌变潜能进行识别。作为头颈病理领域的重要问题之一, 白斑癌变生物标志物的筛选将有助于鳞癌的早期诊断。本文通过综述白斑癌变相关生物标志物的相关研究, 探讨从基础科研到临床转化的前景。目前虽尚无生物标志物应用于临床, 但基因组不稳定性可能是一种具有应用前景的辅助方法。
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Nos. 81671006 and 81300894), the CAMS Innovation Fund for Medical Sciences (No. 2019-I2M-5-038), the National Clinical Key Discipline Construction Project (No. PKUSSNKP-202102), the Program for New Clinical Techniques and Therapies of Peking University Hospital of Stomatology (No. PKUSSNCT-22A14), and the Innovation Fund for Outstanding Doctoral Candidates of Peking University Health Science Center (No. BMU2022BSS001), China.
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Tiejun LI and Heyu ZHANG: contributed to conception and design, and critically revised the manuscript. Xinjia CAI: contributed to conception, design, data acquisition and interpretation, and drafted the manuscript. Jianyun ZHANG: contributed to conception, data acquisition and interpretation, and drafted the manuscript. All authors have read and approved the final manuscript.
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Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, and Tiejun LI declare that they have no conflict of interest.
This review does not contain any studies with human or animal subjects performed by any of the authors.
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Cai, X., Zhang, J., Zhang, H. et al. Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside. J. Zhejiang Univ. Sci. B 24, 868–882 (2023). https://doi.org/10.1631/jzus.B2200589
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DOI: https://doi.org/10.1631/jzus.B2200589